669763-28-4Relevant academic research and scientific papers
Chemical synthesis of 4-azido-β-galactosamine derivatives for inhibitors of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
Hor, Seanghai,Kodama, Takumi,Sugiura, Nobuo,Kondou, Hikaru,Yanagida, Mio,Yanagisawa, Keiya,Shibasawa, Aoki,Tsuzuki, Bunta,Fukatsu, Naoto,Nagao, Kazuya,Yamana, Kenji,Hidari, Kazuya I. P. J.,Watanabe, Hideto,Habuchi, Osami,Nakano, Hirofumi
, p. 477 - 491 (2018)
Chondroitin sulfate E (CS-E) plays a crucial role in diverse processes ranging from viral infection to neuroregeneration. Its regiospecific sulfation pattern, generated by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST), is the main structural determinant of its biological activity. Inhibitors of GalNAc4S-6ST can serve as powerful tools for understanding physiological functions of CS-E and its potential therapeutic leads for human diseases. A family of new 4-acylamino-β-GalNAc derivatives and 4-azido-β-GalNAc derivatives were synthesized for their potential application as inhibitors of GalNAc4S-6ST. The target compounds were evaluated for their inhibitory activities against GalNAc4S-6ST. The results revealed that 4-pivaloylamino- and 4-azido-β-GalNAc derivatives displayed evident activities against GalNAc4S-6ST with IC50 value ranging from 0.800 to 0.828?mM. They showed higher activities than benzyl D-GalNAc4S that was used as control.
