67-21-0 Usage
Chemical Properties
Off-White Solid
Uses
Different sources of media describe the Uses of 67-21-0 differently. You can refer to the following data:
1. antineoplastic; inhibitor DNA methylation
2. DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. It is also used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.
Definition
ChEBI: A non-proteinogenic alpha-amino acid that is methionine in which the S-methyl group is replaced by an S-ethyl group.
General Description
White crystalline flakes.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
A synthetic thio-substituted amino acid.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition DL-ETHIONINE emits toxic fumes of NOx and SOx.
Fire Hazard
Flash point data for DL-ETHIONINE are not available; however, DL-ETHIONINE is probably combustible.
Biochem/physiol Actions
DL-Ethionine is a racemic mixture of the anti-methylation agent L-Ethionine and its enantiomer D-Ethionine. DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. DL-Ethionine is used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.
Safety Profile
Mddly toxic by
ingestion and intraperitoneal routes.
Suspected carcinogen with experimental
carcinogenic and tumorigenic data. An
experimental teratogen. Experimental reproductive effects. Mutation data
reported. When heated to decomposition it
emits toxic fumes of SOx and NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 67-21-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 67-21:
(4*6)+(3*7)+(2*2)+(1*1)=50
50 % 10 = 0
So 67-21-0 is a valid CAS Registry Number.
InChI:InChI=1/2C6H13NO2S/c2*1-2-10-4-3-5(7)6(8)9/h2*5H,2-4,7H2,1H3,(H,8,9)/t2*5-/m10/s1
67-21-0Relevant articles and documents
Rationally engineered variants of S-adenosylmethionine (SAM) synthase: Reduced product inhibition and synthesis of artificial cofactor homologues
Dippe,Brandt,Rost,Porzel,Schmidt,Wessjohann
supporting information, p. 3637 - 3640 (2015/03/30)
S-Adenosylmethionine (SAM) synthase was engineered for biocatalytic production of SAM and long-chain analogues by rational re-design. Substitution of two conserved isoleucine residues extended the substrate spectrum of the enzyme to artificial S-alkylhomocysteines. The variants proved to be beneficial in preparative synthesis of SAM (and analogues) due to a much reduced product inhibition. This journal is
Deamination and γ-Addition Reactions of Vinylglycine Catalyzed by Yeast Kynurenine Aminotransferase, and Suicidal Inactivation of the Enzyme during Its Processing
Asada, Yasuhiko,Tanizawa, Katsuyuki,Yonaha, Kazuo,Soda, Kenji
, p. 2873 - 2878 (2007/10/02)
Kynurenine aminotransferase from a yeast, Hansenula schneggii, has been found to catalyze the deamination of an olefinic amino acid, L-vinylglycine, to form α-ketobutyrate and ammonia.The maximum rate of deamination was 0.17 μmol/mg/min at 25 deg C (pH 8.0), which is approximately 1percent of the rate of transamination between L-kynurenine and α-ketoglutarate.Concomitantly with the catalysis, the enzyme lost both the deaminase and aminotransferase activities in a time-dependent manner.The inactivation was irreversible and followed pseudo-first-order kinetics at various concentrations of L-vinylglycine.The Michaelis constant for L-vinylglycine in the inactivation reaction was essentially the same as that in the deamination.These results indicate that the two reactions proceed through a common intermediary complex, and L-vinylglycine acts as a suicide inactivator for the enzyme.The apoenzyme neither catalyzed the deamination nor was inactivated by L-vinylglycine.The enzyme also catalyzes the γ-addition reaction of L-vinylglycine in the presence of alkanethiols producing the corresponding S-substituted homocysteines.
