Welcome to LookChem.com Sign In|Join Free

CAS

  • or
DL-ETHIONINE, also known as a non-proteinogenic alpha-amino acid, is a derivative of methionine where the S-methyl group is replaced by an S-ethyl group. It appears as white crystalline flakes and has off-white solid chemical properties. DL-ETHIONINE is a compound with various applications in different industries, particularly in the field of research and pharmaceuticals.

67-21-0 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 67-21-0 Structure
  • Basic information

    1. Product Name: DL-ETHIONINE
    2. Synonyms: DL-ETHIONINE;DL-2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID;2-AMINO-4-ETHYLMERCAPTOBUTYRIC ACID;2-AMINO-4-(ETHYLTHIO) BUTYRIC ACID;S-ETHYL-DL-HOMOCYSTEINE;(.+/-.)-Ethionine;(+-)-ethionine;)-Ethionine
    3. CAS NO:67-21-0
    4. Molecular Formula: C6H13NO2S
    5. Molecular Weight: 163.24
    6. EINECS: 200-647-0
    7. Product Categories: Sulphur Derivatives;Amino Acids 13C, 2H, 15N;Amino acids methyl、ethyl、t-butyl series;Amino Acids & Derivatives;Sulfur & Selenium Compounds
    8. Mol File: 67-21-0.mol
  • Chemical Properties

    1. Melting Point: 265-268 °C
    2. Boiling Point: 310℃
    3. Flash Point: 142℃
    4. Appearance: White to off-white/Crystalline Powder or Flakes
    5. Density: 1.164
    6. Vapor Pressure: 1.49E-13mmHg at 25°C
    7. Refractive Index: 1.5500 (estimate)
    8. Storage Temp.: −20°C
    9. Solubility: Methanol (Slightly, Heated), Water (Slightly)
    10. PKA: 2.23±0.10(Predicted)
    11. Water Solubility: Soluble in water.
    12. Merck: 14,3738
    13. BRN: 1722529
    14. CAS DataBase Reference: DL-ETHIONINE(CAS DataBase Reference)
    15. NIST Chemistry Reference: DL-ETHIONINE(67-21-0)
    16. EPA Substance Registry System: DL-ETHIONINE(67-21-0)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS: ES6825200
    6. TSCA: Yes
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 67-21-0(Hazardous Substances Data)

67-21-0 Usage

Uses

Used in Pharmaceutical and Research Applications:
DL-ETHIONINE is used as an antineoplastic agent, which means it has the potential to inhibit the growth and development of cancer cells. It is particularly useful in the study of cholangiocarcinogenesis, a type of bile duct cancer, as it can accelerate the process in vivo when used as a dietary supplement. This application aids researchers in understanding the disease's progression and developing potential treatments.
Additionally, DL-ETHIONINE is used as an inhibitor of DNA methylation, a process that plays a crucial role in the regulation of gene expression and has been linked to various diseases, including cancer. By inhibiting this process, DL-ETHIONINE can help researchers study the effects of altered DNA methylation patterns on cellular function and disease development.
Used in Liver Research:
DL-ETHIONINE is also used to induce oxidative stress in the liver, which allows researchers to study the levels and activities of anti-oxidative enzymes and compounds, such as glutathione. This application is essential for understanding the body's response to oxidative stress and the role of antioxidants in maintaining liver health.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

A synthetic thio-substituted amino acid.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition DL-ETHIONINE emits toxic fumes of NOx and SOx.

Fire Hazard

Flash point data for DL-ETHIONINE are not available; however, DL-ETHIONINE is probably combustible.

Biochem/physiol Actions

DL-Ethionine is a racemic mixture of the anti-methylation agent L-Ethionine and its enantiomer D-Ethionine. DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. DL-Ethionine is used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.

Safety Profile

Mddly toxic by ingestion and intraperitoneal routes. Suspected carcinogen with experimental carcinogenic and tumorigenic data. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.

Check Digit Verification of cas no

The CAS Registry Mumber 67-21-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 67-21:
(4*6)+(3*7)+(2*2)+(1*1)=50
50 % 10 = 0
So 67-21-0 is a valid CAS Registry Number.
InChI:InChI=1/2C6H13NO2S/c2*1-2-10-4-3-5(7)6(8)9/h2*5H,2-4,7H2,1H3,(H,8,9)/t2*5-/m10/s1

67-21-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (E0038)  DL-Ethionine  >98.0%(T)

  • 67-21-0

  • 5g

  • 840.00CNY

  • Detail
  • TCI America

  • (E0038)  DL-Ethionine  >98.0%(T)

  • 67-21-0

  • 25g

  • 2,790.00CNY

  • Detail
  • Alfa Aesar

  • (A13154)  DL-Ethionine, 98%   

  • 67-21-0

  • 1g

  • 274.0CNY

  • Detail
  • Alfa Aesar

  • (A13154)  DL-Ethionine, 98%   

  • 67-21-0

  • 5g

  • 888.0CNY

  • Detail
  • Alfa Aesar

  • (A13154)  DL-Ethionine, 98%   

  • 67-21-0

  • 25g

  • 2206.0CNY

  • Detail

67-21-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name S-ethylhomocysteine

1.2 Other means of identification

Product number -
Other names cn8676

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:67-21-0 SDS

67-21-0Relevant articles and documents

Rationally engineered variants of S-adenosylmethionine (SAM) synthase: Reduced product inhibition and synthesis of artificial cofactor homologues

Dippe,Brandt,Rost,Porzel,Schmidt,Wessjohann

supporting information, p. 3637 - 3640 (2015/03/30)

S-Adenosylmethionine (SAM) synthase was engineered for biocatalytic production of SAM and long-chain analogues by rational re-design. Substitution of two conserved isoleucine residues extended the substrate spectrum of the enzyme to artificial S-alkylhomocysteines. The variants proved to be beneficial in preparative synthesis of SAM (and analogues) due to a much reduced product inhibition. This journal is

Palatability of aquaculture feed

-

, (2008/06/13)

A method for enhancing the palatability of aquaculture food, the method comprising treating the food with a compound of Formula I: wherein R1, R2, R3, and n are as defined herein, are disclosed.

Deamination and γ-Addition Reactions of Vinylglycine Catalyzed by Yeast Kynurenine Aminotransferase, and Suicidal Inactivation of the Enzyme during Its Processing

Asada, Yasuhiko,Tanizawa, Katsuyuki,Yonaha, Kazuo,Soda, Kenji

, p. 2873 - 2878 (2007/10/02)

Kynurenine aminotransferase from a yeast, Hansenula schneggii, has been found to catalyze the deamination of an olefinic amino acid, L-vinylglycine, to form α-ketobutyrate and ammonia.The maximum rate of deamination was 0.17 μmol/mg/min at 25 deg C (pH 8.0), which is approximately 1percent of the rate of transamination between L-kynurenine and α-ketoglutarate.Concomitantly with the catalysis, the enzyme lost both the deaminase and aminotransferase activities in a time-dependent manner.The inactivation was irreversible and followed pseudo-first-order kinetics at various concentrations of L-vinylglycine.The Michaelis constant for L-vinylglycine in the inactivation reaction was essentially the same as that in the deamination.These results indicate that the two reactions proceed through a common intermediary complex, and L-vinylglycine acts as a suicide inactivator for the enzyme.The apoenzyme neither catalyzed the deamination nor was inactivated by L-vinylglycine.The enzyme also catalyzes the γ-addition reaction of L-vinylglycine in the presence of alkanethiols producing the corresponding S-substituted homocysteines.

Sulfur containing trialkoxybenzoylamino carboxylic acids

-

, (2008/06/13)

Compounds are prepared of the formula: STR1 wherein A is a straight or branched chain alkylene or alkylidene radical having 2 to 5 carbon atoms and which is substituted by an alkylthio group having 1 to 4 carbon atoms, a carboxymethyl thio group, a carboxyethyl thio group, an alkylsulfonyl group having 1 to 4 carbon atoms, a mercapto group, or the substituent on A together with --COR4 forms a 4 to 7 membered thiolactone ring, or A is substituted by an acylmercapto group wherein the acyl is benzoyl, a benzoyl radical substituted with one, two or three alkoxy groups with 1 to 6 carbon atoms, an alkanoyl radical of 1 to 6 carbon atoms, an alkenoyl radical of 3 to 6 carbon atoms, R1, R2 and R3 are the same or different and are alkyl groups of 1 to 5 carbon atoms and one of R1, R2 and R3 also can be hydrogen or the acyl radical of an alkanoic acid of 2 to 4 carbon atoms and R4 is a hydroxy group or an alkoxy group with 1 to 5 carbon atoms and their pharmacologically acceptable salts. The compounds are pharmacodynamically active and are suited for prophylaxis and treatment of heart illnesses such as cardiac ischemia, cardiac infarct, heart rhythm and circulatory disturbances.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 67-21-0