6701-13-9Relevant articles and documents
METHOD FOR PRODUCING (METH)ACRYLATE COMPOUND CONTAINING HYDROXYL GROUP AND METHOD FOR PRODUCING (METH)ACRYLATE COMPOUND CONTAINING PHOSPHORIC ACID GROUP
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Paragraph 0054-0057, (2021/09/29)
PROBLEM TO BE SOLVED: To provide a method for producing a (meth)acrylate compound containing a hydroxyl group, which, when producing a (meth)acrylate compound containing a hydroxyl group, can suppress formation of by-products. SOLUTION: Provided is a method for producing a (meth)acrylate compound (A) which is a (meth)acrylate compound containing a hydroxyl group, comprising a step of reacting an alcohol compound containing a halogen atom and a (meth)acrylic acid salt to obtain the (meth)acrylate compound (A). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
COLORED COMPOSITION
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Paragraph 0223, (2016/05/02)
The present invention is to provide a colored composition having higher heat resistance compared with conventional colored compositions. The present invention further relates to: “a polymer having a monomer unit derived from a monomer which has (i) a cationic rhodamine derivative having, as an counter anion, an anion including an aryl group having an electron-withdrawing substituent and an anion group and (ii) an ethylenically unsaturated bond”, “a monomer which has (i) a cationic rhodamine derivative having, as an counter anion, an anion including an aryl group having an electron-withdrawing substituent and an anion group and (ii) an ethylenically unsaturated bond”, “a colored composition comprising the above-described polymer or the monomer”, and “a colored composition for a color filter comprising the above-described polymer or the monomer”.
Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD
Allegretta, Giuseppe,Weidel, Elisabeth,Empting, Martin,Hartmann, Rolf W.
, p. 351 - 359 (2015/02/19)
A new strategy for treating Pseudomonas aeruginosa infections could be disrupting the Pseudomonas Quinolone Signal (PQS) quorum sensing (QS) system. The goal is to impair communication among the cells and, hence, reduce the expression of virulence factors and the formation of biofilms. PqsD is an essential enzyme for the synthesis of PQS and shares some features with chalcone synthase (CHS2), an enzyme expressed in Medicago sativa. Both proteins are quite similar concerning the size of the active site, the catalytic residues and the electrostatic surface potential at the entrance of the substrate tunnel. Hence, we evaluated selected substrates of the vegetable enzyme as potential inhibitors of the bacterial protein. This similarity-guided approach led to the identification of a new class of PqsD inhibitors having a catechol structure as an essential feature for activity, a saturated linker with two or more carbons and an ester moiety bearing bulky substituents. The developed compounds showed PqsD inhibition with IC50 values in the single-digit micromolar range. The binding mode of these compounds was investigated by Surface Plasmon Resonance (SPR) experiments revealing that their interaction with the protein is not influenced by the presence of the anthranilic acid bound to active site cysteine. Importantly, some compounds reduced the signal molecule production in cellulo.