67014-20-4Relevant articles and documents
Synthesis and biologic distribution of radioiodinated β-adrenergic antagonists
Hanson,Holman,Davis
, p. 830 - 833 (1978)
Iodinated analogues were prepared from propranolol, practolol, and acebutolol in 30-50% yields. Radioisotopic exchange between carrier-free Na 125I and the molten iodinated β-adrenergic antagonist yielded the corresponding 125I-labeled product. The biodistribution in rats, determined at 15 and 60 min postinjection, indicated that the radioiodinated analogues of the cardioselective drugs practolol and acebutolol localized to a greater degree in the liver and heart than the analogue of propranolol. Conversely,[125I]iodopropranolol was concentrated to a greater extent in the lungs than [125I]iodopractolol or [125I]iodoacebutolol. Therefore, 123I- or 131I-labeled cardioselective β-adrenergic antagonists may prove useful as radiodiagnostic agents for the external imaging of the myocardium.
