670221-38-2

Upstream product

• 41998-17-8 phenyl 3-chlorobenzoate 
• 61002-52-6 3-chlorophenyl 4-hydroxyphenyl ketone 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 670221-35-9 [4-(3-chloro-benzoyl)-phenoxy]-acetic acid hydrazide 
• 670221-32-6 C₂₃H₂₀ClN₃O₃S 

Relevant academic research and scientific papers

Synthesis of 5-(4′-aroyl)-aryloxy methyl-4H-(1,2,4)-triazolin-3-thiol and their biological activity

5-(4′-aroyl)-aryloxy methyl-4H-1,2, 4)-triazolin-3-thiols were synthesized by using substituted phenyl benzoates as the starting material. Phenyl benzoates on Fries rearrangement gave p-hydroxy benzophenones which on treatment with ethyl bromoacetate in presence of anhydrous potassium carbonate and dry acetone gave corresponding benzoyl phenyloxy esters in excellent yield. Esters were refluxed with thiosemicarbazide in presence of acetic anhydride gave cyclized title compounds. Supports for the structures of the synthesized compounds have been provided by their elemental analysis and spectral data. The newly synthesized compounds were screened for antibacterial and antifungal activities.

Synthesis and antimicrobial activity of 5-[(4-aroyl) aryloxymethyl]-2-(4-methylphenylamino)-1,3,4-thiadiazoles and 5-[(4-aroyl) aryloxy methyl]-4-(4-methylphenyl)-3-mercapto-4H-1,2,4-triazoles

Aroyl aryloxyacetic thiosemicarbazides 4a-d have been synthesized by the reaction of acid hydrazides 3a-d with p-tolyl isothiocyanate. The aroyl aryloxyacetic thiosemicarbazides 4a-d on intramolecular cyclization using conc.H2SO4 and