670234-44-3

Upstream product

• 86448-92-2 methyl 1-bromo-1-desoxy-O²,O³,O⁴-tri(2,2-dimethyl-1-oxopropyl)-α-D-glucuronate 
• 670234-43-2 2-nitro-3-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethylamino}phenol 
• 57061-71-9 1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane 
• 27144-85-0 2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethan-1-amine 
• 670234-48-7 1-(2-azidoethyl)-4-(3-trifluoromethylphenyl)piperazine 

Downstream Products

• 670234-49-8 (2S,3S,4S,5R,6S)-3,4,5-Tris-(2,2-dimethyl-propionyloxy)-6-(2-oxo-1-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-2,3-dihydro-1H-benzoimidazol-4-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Accelerated Koenigs - Knorr Glucuronidation of a Deactivated Nitrophenol: Unveiling the Role of Polyamine Additive 1,1,4,7,10,10-Hexamethyltriethylenetetramine1 through Design of Experiments

1,1,4,7,10,10-Hexamethyltriethylenetetramine (HMTTA) emerged from a limited parallel screening of selected polyamines as the most appropriate additive for an especially problematic Koenigs-Knorr glucuronidation. This initial finding rapidly evolved into a