27144-85-0

Basic information

• Product Name: 2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanamine
• Synonyms: 2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanamine;2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethanamine;2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethylamine
• CAS NO: 27144-85-0
• Molecular Formula: C₁₃H₁₈F₃N₃
• Molecular Weight: 273.3
• Mol File: 27144-85-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanamine(27144-85-0)
• EPA Substance Registry System: 2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanamine(27144-85-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 27144-85-0(Hazardous Substances Data)

Usage

General Description

2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanamine is a chemical compound with the molecular formula C14H19F3N2. It is a piperazine derivative with a trifluoromethylphenyl group attached to the piperazine ring. 2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanamine is used in pharmaceutical research and may have potential applications in the development of new drugs. It may also have biological activity as a receptor agonist or antagonist, or as a modulator of neurotransmitter systems. Due to its structural features, 2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanamine may have potential therapeutic uses in various medical conditions. Further research is needed to fully understand the pharmacological properties and potential applications of this compound.

Upstream product

• 15532-75-9 1-(3-Trifluoromethylphenyl)piperazine 
• 670234-48-7 1-(2-azidoethyl)-4-(3-trifluoromethylphenyl)piperazine 
• 57061-71-9 1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane 

Downstream Products

• 82608-07-9 N-<2-<4-(3-trifluoromethylphenyl)-1-piperazinyl>ethyl>2-methoxy-5-methyl sulfamoylbenzamide 
• 82608-06-8 N-<2-<4-(3-trifluoromethylphenyl)-1-piperazinyl>ethyl>2-methoxy-5-methyl sulfonylbenzamide 
• 63556-33-2 2-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-[1,2]thiazinane 1,1-dioxide 
• 63556-32-1 1-[2-(1,1-dioxo-1λ⁶-isothiazolidin-2-yl)-ethyl]-4-(3-trifluoromethyl-phenyl)-piperazine 
• 2101958-02-3 ethyl 4-((3,4-dioxo-2-((2-(4-(3-(trifluoromethyl)-phenyl)-piperazin-1-yl)-ethyl)-amino)-cyclobut-1-en-1-yl)-amino)-piperidine-1-carboxylate 
• 1240266-60-7 C₂₆H₃₁F₃N₄O*ClH 
• 1262099-32-0 C₂₃H₂₄F₃N₃O₂ 
• 1221290-72-7 N-{2-[4-(3-trifluoro-methylphenyl)piperazin-1-yl]ethyl}-2-quinoxaline carboxamide 
• 1221290-95-4 N-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-3-quinoline carboxamide 
• 1221290-82-9 N-{2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethyl}-2-quinoline carboxamide 
• 1155401-86-7 N-[2-{4-(3-trifluoromethylphenyl)-piperazin-1-yl}-ethyl]-3-(2-methylphenyl)-pyrrolidine-2,5-dione hydrochloride 
• 1155401-95-8 N-[2-{4-(3-trifluoromethylphenyl)-piperazin-1-yl}-ethyl]-3-(2-trifluoromethylphenyl)-pyrrolidine-2,5-dione hydrochloride 
• 164389-06-4 4-butyl-3,5-dioxo-(2H, 4H)-6-(2-(4-(3-trifluoromethylphenyl)piperazino)ethylamino)-1,2,4-triazine 
• 164389-00-8 2,4-dimethyl-3,5-dioxo (2H, 4H)-6-(2-(4-(3-trifluoromethylphenyl)piperazino)ethylamino)-1,2,4-triazine 

Relevant articles and documents

Small-Molecule Inhibition of the UNC119–Cargo Interaction

N-Terminal myristoylation facilitates membrane binding and activity of proteins, in particular of Src family kinases, but the underlying mechanisms are only beginning to be understood. The chaperones UNC119A/B regulate the cellular distribution and signal

Chemical modifications on 4-arylpiperazine-ethyl carboxamide derivatives differentially modulate affinity for 5-HT1A, D4.2, and α2A receptors: Synthesis and in vitro radioligand binding studies

A series of substituted 4-aryl-piperazine-ethyl heteroarylcarboxamides were prepared and tested in in vitro radioligand binding studies. The presence of a quinoxaline has a favourable impact in terms of serotonin 5-HT1A versus dopamine D4.2 receptor selectivity. Compounds with a 3-CF3 group at the distal phenyl ring are the most effective in terms of affinity and selectivity for 5-HT1A versus D4.2 receptors. A 4-phenyl-1,2,3,6- tetrahydropyridine in place of the corresponding 4-phenyl-piperazine side chain is also favourable not only for the affinity for 5-HT1A and D4.2 receptors but also in some cases for α2A-adrenoceptors.

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

A small molecule library of piperazinylalkylisoxazole derivatives containing about 600 compounds was designed, synthesized and evaluated for blocking effects on T-type Ca2+ channel. Several ligands were identified to possess high inhibitory activity against the T-type Ca 2+ channel. The compound 21 with trifluoromethyl substituents at C3-position of phenyl group (R1) and C2- position of phenyl group (R2) showed the highest inhibitory activity with IC50 value of 1.02μM, which is comparable to that of mibefradil.