67024-70-8Relevant academic research and scientific papers
Synthesis of benzofurans from the cyclodehydration of α-phenoxy ketones mediated by Eaton’s reagent
Ma, Lin,Ma, Zhanwei,Zhang, Min,Zhou, Min
, p. 426 - 436 (2020/03/23)
Cyclodehydration of α-phenoxy ketones promoted by Eaton’s reagent (phosphorus pentoxide–methanesulfonic acid) is used to prepare 3-substituted or 2,3-disubstituted benzofurans with moderate to excellent yields under mild conditions. The method provides a facile access to benzofurans from readily available starting materials such as phenols and α-bromo ketones. The reaction is highly efficient, which is attributed to the good reactivity and fluidity of Eaton’s reagent. The reaction can be applied to prepare naphthofurans, furanocoumarins, benzothiophenes, and benzopyrans.
Clay catalyzed facile cyclodehydration under microwave: Synthesis of 3-substituted benzofurans
Meshram,Chandra Sekhar,Ganesh,Yadav
, p. 1273 - 1274 (2007/10/03)
The preparation of 3-substituted benzofurans from α-phenoxy acetophenones and related compounds using clay under microwave irradiation is described. The inexpensive, reusable clay and non-solvent reaction conditions are the important features of the proce
