670256-96-9Relevant academic research and scientific papers
Highly diastereoselective synthesis of arylglycine derivatives via TFA-promoted Friedel-Crafts reactions of phenols with cyclic glyoxylate imines
Chen, Yong-Jun,Lei, Fei,Liu, Li,Wang, Dong
, p. 7609 - 7614 (2007/10/03)
Optically active α-arylglycine derivatives were synthesized by Br?nsted acid (TFA)-promoted Friedel-Crafts reaction of various phenols with chiral cyclic glyoxylate imines (2a-c), followed by deprotection with Pd(OH)2/C under H2. The diastereoselectivities of the initially formed F-C reaction products are up to 99%.
