670261-50-4Relevant academic research and scientific papers
Solvent-free synthesis of 1-[3-alkyl-4-methyl-2-thioxo-2,3-dihydrothiazole- 5-yl]-ethanones in a multicomponent reaction
Iravani, Nasir,Karami, Bahador,Asadimoghaddam, Farideh,Monfared, Maryam,Karami, Nahid
, p. 279 - 284 (2012)
A simple and efficient one-pot synthesis of 1-[3-alkyl-4-methyl-2-thioxo-2, 3-dihydrothiazole-5-yl]- ethanones from the reaction of primary alkylamines and carbon disulfide in the presence of 3-chloro acetylacetone is described. This protocol has several advantages such as lack of need for a solvent and catalyst, high yields, mild conditions and short reaction times.
