670266-26-9

Basic information

• Product Name: N-(3-chlorophenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide
• Synonyms: N-(3-chlorophenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide
• CAS NO: 670266-26-9
• Molecular Formula: C17H11ClN2O3S
• Molecular Weight: 358.79884
• Mol File: 670266-26-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-chlorophenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-chlorophenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide(670266-26-9)
• EPA Substance Registry System: N-(3-chlorophenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide(670266-26-9)

Safety Data

• Hazardous Substances Data: 670266-26-9(Hazardous Substances Data)

Upstream product

• 50964-11-9 6-aminobenzindol-2(1H)-one 
• 34599-42-3 6-nitrobenzindol-2(1H)-one 
• 78078-92-9 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonyl chloride 
• 108-42-9 3-chloro-aniline 
• 130-00-7 1,8-naphtholactam 
• 81-84-5 1,8-Naphthalic anhydride 
• 7797-81-1 N-hydroxy-1,8-naphthalenedicarboximide 

Relevant articles and documents

Design, synthesis and biological evaluation of naphthostyril derivatives as novel protein kinase FGFR1 inhibitors

New class of FGFR1 kinase inhibitors with naphthostyril heterocycle has been identified. A series of N-phenylnaphthostyril-1-sulfonamides has been synthesized and tested in vitro. It was revealed that the most active compound N-(4-hydroxyphenyl)naphthostyril-1- sulfonamide inhibited FGFR1 with IC50 of 2 μM. In our preliminary studies, N-phenylnaphthos-tyril- 1-sulfonamides demonstrated selectivity of FGFR1 inhibition and antiproliferative activity on cancer cell line. N-phenylnaphthostyril-1-sulfonamides have a good potential for further development as anticancer agents.