670280-45-2

Upstream product

• 79-08-3 bromoacetic acid 
• 18590-76-6 2-(2-chlorophenyl)-4(3H)-quinazolinethione 
• 670280-39-4 3-allyl-2-(2-chlorophenyl)-4(3H)-quinazolinethione 
• 4765-51-9 2-(2-chlorophenyl)benzo[d]1,3-oxazin-4-one 
• 69949-33-3 2-(2-chlorophenyl)-4H-3,1-benzothiazine-4-thione 

Relevant academic research and scientific papers

Studies on quinazolines. Part III. Synthesis of some fused-ring cationic and mesoionic derivatives of the 1,3-thiazolo[3,2-c]quinazoline ring system

4-Allylthio-2-arylquinazolines 4a-c undergo cyclization by action of bromine to furnish 5-aryl-3-bromomethyl-2,3-dihydrothiazolo[3,2-c]quinazolin-4- ium bromide 5a-c. Compounds 5a-c undergo ring opening by action of water under acid catalysis to afford th

Cationic and mesoionic 1,3-thiazolo-[3,2-c]quinazoline derivatives

4-Allylthio-2-arylquinazolines 4a-c undergo cyclization by action of bromine to furnish 5-aryl-3-bromomethyl-2,3-dihydrothiazolo[3,2-c]quinazolin-4-ium bromides 5a-c. Compounds 5a-c undergo ring opening by action of water under acid catalysis to afford the corresponding dibromide derivatives 6a-c. Bromination of 3-allyl-2-aryl-4(3H)quinazolinethiones 7a-c leads to 5-aryl-2-bromomethyl-2,3-dihydrothiazolo[3,2-c]quinazolin-4-ium bromides 8a-c. However, anhydro-3-hydroxy-5-aryl-1,3-thiazolo[3,2-c]quinazolin-4-ium hydroxide 10a-c were prepared by the cyclodehydration of the corresponding thioglycolic acids 9a-c with Ac2O.