18590-76-6

Basic information

• Product Name: 2-(2-CHLOROPHENYL)QUINAZOLINE-4(3H)-THIONE
• Synonyms: 2-(2-chlorophenyl)-1H-quinazoline-4-thione
• CAS NO: 18590-76-6
• Molecular Formula: C₁₄H₉ClN₂S
• Molecular Weight: 0
• Mol File: 18590-76-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 434.3°Cat760mmHg
• Flash Point: 216.5°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 9.56E-08mmHg at 25°C
• Refractive Index: 1.702
• CAS DataBase Reference: 2-(2-CHLOROPHENYL)QUINAZOLINE-4(3H)-THIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLOROPHENYL)QUINAZOLINE-4(3H)-THIONE(18590-76-6)
• EPA Substance Registry System: 2-(2-CHLOROPHENYL)QUINAZOLINE-4(3H)-THIONE(18590-76-6)

Safety Data

• Hazardous Substances Data: 18590-76-6(Hazardous Substances Data)

Usage

Chemical class

Quinazoline derivatives

Type of compound

Heterocyclic compound with a thione functional group

Pharmacological activities

Anticonvulsant, antifungal, and antibacterial properties

Potential use

Antitumor agent

Structural properties

Presence of chlorophenyl group and quinazoline core make it suitable for further development and research into therapeutic applications.

InChI:InChI=1/C14H9ClN2S/c15-11-7-3-1-5-9(11)13-16-12-8-4-2-6-10(12)14(18)17-13/h1-8H,(H,16,17,18)

Upstream product

• 4765-51-9 2-(2-chlorophenyl)benzo[d]1,3-oxazin-4-one 
• 89-98-5 2-chloro-benzaldehyde 
• 4765-50-8 2-(2-chlorophenyl)quinazolin-4(3H)-one 
• 13324-80-6 2-(2-chlorophenyl)-1,2-dihydro-4(3H)-quinazolinone 
• 28144-70-9 anthranilic acid amide 
• 69949-33-3 2-(2-chlorophenyl)-4H-3,1-benzothiazine-4-thione 

Downstream Products

• 332850-65-4 C₁₄H₁₁ClN₄ 
• 1448068-42-5 C₁₅H₁₀ClN₅ 
• 670280-30-5 4-allylthio-2-(2-chlorophenyl)quinazoline 
• 670280-45-2 4-carboxymethylthio-2-(2-chlorophenyl)quinazoline 

Relevant articles and documents

2-Alkyl(aryl)-quinazolin-4(3 H)-thiones, 2-R-(quinazolin-4(3 H)-ylthio)carboxylic acids and amides: Synthesis, molecular docking, antimicrobial and anticancer properties

In this study, a series of novel 2-alkyl(aryl)-quinazolin-4(3H)-thiones, 2-R-(quinazolin-4(3H)-ylthio)carboxylic acids and amides were synthesized and evaluated for antimicrobial and anticancer activities. Their structure was confirmed by elemental analys

Cationic and mesoionic 1,3-thiazolo-[3,2-c]quinazoline derivatives

4-Allylthio-2-arylquinazolines 4a-c undergo cyclization by action of bromine to furnish 5-aryl-3-bromomethyl-2,3-dihydrothiazolo[3,2-c]quinazolin-4-ium bromides 5a-c. Compounds 5a-c undergo ring opening by action of water under acid catalysis to afford the corresponding dibromide derivatives 6a-c. Bromination of 3-allyl-2-aryl-4(3H)quinazolinethiones 7a-c leads to 5-aryl-2-bromomethyl-2,3-dihydrothiazolo[3,2-c]quinazolin-4-ium bromides 8a-c. However, anhydro-3-hydroxy-5-aryl-1,3-thiazolo[3,2-c]quinazolin-4-ium hydroxide 10a-c were prepared by the cyclodehydration of the corresponding thioglycolic acids 9a-c with Ac2O.