6703-19-1 Usage
Uses
Used in Pharmaceutical Applications:
(9cis,13cis)-12-carboxyretinoic acid is used as a therapeutic agent for the treatment of various diseases, including cancer, dermatological disorders, and metabolic diseases. Its application is based on its ability to interact with retinoic acid receptors, affecting gene transcription and cellular processes, which can lead to the regulation of cell growth, differentiation, and immune function.
Used in Cancer Treatment:
In the field of oncology, (9cis,13cis)-12-carboxyretinoic acid is used as a potential treatment option for various types of cancer. Its role in cell growth regulation and gene expression makes it a promising candidate for cancer therapy, as it may help in controlling tumor growth and progression.
Used in Dermatological Applications:
(9cis,13cis)-12-carboxyretinoic acid is also used in dermatology for the treatment of skin disorders. Its influence on cell differentiation and gene expression can contribute to the improvement of skin conditions and promote healthy skin function.
Used in Metabolic Disease Treatment:
Furthermore, (9cis,13cis)-12-carboxyretinoic acid is utilized in the treatment of metabolic diseases due to its role in regulating gene expression and cellular processes that are essential for maintaining proper metabolic function.
Used in Vision and Immune Function:
Additionally, (9cis,13cis)-12-carboxyretinoic acid is used in applications related to vision and immune function, as it plays a role in the regulation of these physiological processes. Its involvement in the control of gene expression and cellular processes can contribute to the maintenance of healthy vision and immune system function.
Check Digit Verification of cas no
The CAS Registry Mumber 6703-19-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,0 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6703-19:
(6*6)+(5*7)+(4*0)+(3*3)+(2*1)+(1*9)=91
91 % 10 = 1
So 6703-19-1 is a valid CAS Registry Number.
6703-19-1Relevant articles and documents
SYNTHETIC INVESTIGATIONS IN THE CHEMISTRY OF POLYENE COMPOUNDS. -- XLVIII. STRUCTURE AND TRANSFORMATIONS OF 12-CARBOXYRETINOIC ACIDS AND THEIR ESTERS. SYNTHESIS OF 13-CIS-RETINOIC ACID
Polyachenko, L. N.,Davydova, L. P.,Darskaya, E. N.,Filippova, T. M.,Samokhvalov, G. I.
, p. 685 - 694 (2007/10/02)
In reaction with ethyl β-methylglutaconate under the influence of alkali in methanol the Z and E isomers of β-ionylideneacetaldehyde form isomeric 9Z,11Z,13Z- and 9E,11Z,13Z-12-carboxyretinoic acids.Decarboxylation of the latter in the pyridine-piperidine system in the presence of copper salts leads to 13Z-retinoic acid and is accompanied by the formation of 9,13-dimethyl-7-(1,1,5-trimethyl-5-cyclohexen-6-yl)-7,9,11,13-octatetraene.The stereoisomeric transformations of 12-substituted 9E,Z,11Z,13Z-retinoic acids and the corresponding diols and diacetates obtained from them were investigated.Isomerization takes place at the double bond at the C9 atom and depends on the nature of the substituent at the C12 atom.
12-Carboxyretinoic Acids. Synthesis and Structure
Lewin, Anita H.,Whaley, M. Glenn,Parker, Steven R.,Carroll, F. Ivy
, p. 1799 - 1807 (2007/10/02)
Four isomeric 12-carboxyretinoic acids and their dimethyl esters (trans, 13-cis, 11-cis, and 11-cis,13-cis), along with two isomeric retinoic anhydrides (13-cis and 11-cis,13-cis), have been prepared and fully characterized.The primary product of the base-promoted condensation of trans-(β-ionylidene)acetaldehyde and β-methylglutaconate has been shown to be the 11-cis,13-cis-diacid.The interconversions and relative stabilities of these retinoids are discussed in terms of their conformations
