6703-19-1 Usage
General Description
(9cis,13cis)-12-carboxyretinoic acid, also known as 9,13-dicis-retinoic acid, is a retinoid derivative that plays a crucial role in various biological processes, including cell growth and differentiation, and regulation of gene expression. This chemical compound is a naturally-occurring metabolite of vitamin A and is involved in the control of numerous physiological functions, such as vision, immune function, and embryonic development. Its therapeutic potential has been investigated in the treatment of various diseases, including cancer, dermatological disorders, and metabolic diseases. It acts through interaction with retinoic acid receptors, which ultimately affect gene transcription and cellular processes. Overall, (9cis,13cis)-12-carboxyretinoic acid is a multifunctional compound with significant importance in human health and disease.
Check Digit Verification of cas no
The CAS Registry Mumber 6703-19-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,7,0 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6703-19:
(6*6)+(5*7)+(4*0)+(3*3)+(2*1)+(1*9)=91
91 % 10 = 1
So 6703-19-1 is a valid CAS Registry Number.
6703-19-1Relevant articles and documents
SYNTHETIC INVESTIGATIONS IN THE CHEMISTRY OF POLYENE COMPOUNDS. -- XLVIII. STRUCTURE AND TRANSFORMATIONS OF 12-CARBOXYRETINOIC ACIDS AND THEIR ESTERS. SYNTHESIS OF 13-CIS-RETINOIC ACID
Polyachenko, L. N.,Davydova, L. P.,Darskaya, E. N.,Filippova, T. M.,Samokhvalov, G. I.
, p. 685 - 694 (2007/10/02)
In reaction with ethyl β-methylglutaconate under the influence of alkali in methanol the Z and E isomers of β-ionylideneacetaldehyde form isomeric 9Z,11Z,13Z- and 9E,11Z,13Z-12-carboxyretinoic acids.Decarboxylation of the latter in the pyridine-piperidine system in the presence of copper salts leads to 13Z-retinoic acid and is accompanied by the formation of 9,13-dimethyl-7-(1,1,5-trimethyl-5-cyclohexen-6-yl)-7,9,11,13-octatetraene.The stereoisomeric transformations of 12-substituted 9E,Z,11Z,13Z-retinoic acids and the corresponding diols and diacetates obtained from them were investigated.Isomerization takes place at the double bond at the C9 atom and depends on the nature of the substituent at the C12 atom.
