6704-35-4

Basic information

• Product Name: 1-MORPHOLIN-4-YLACETONE
• Synonyms: 1-MORPHOLIN-4-YLACETONE;1-(4-morpholinyl)acetone(SALTDATA: FREE);1-morpholin-4-ylpropan-2-one;1-morpholinoacetone;1-morpholinopropan-2-one
• CAS NO: 6704-35-4
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18362
• Mol File: 6704-35-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 145.5 °C
• Boiling Point: 207.754°C at 760 mmHg
• Flash Point: 79.447°C
• Appearance: /
• Density: 1.024g/cm³
• Vapor Pressure: 0.222mmHg at 25°C
• Refractive Index: 1.451
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 5.06±0.10(Predicted)
• CAS DataBase Reference: 1-MORPHOLIN-4-YLACETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-MORPHOLIN-4-YLACETONE(6704-35-4)
• EPA Substance Registry System: 1-MORPHOLIN-4-YLACETONE(6704-35-4)

Safety Data

• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 6704-35-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 4389, 1987 DOI: 10.1021/jo00228a046

InChI:InChI=1/C7H13NO2/c1-7(9)6-8-2-4-10-5-3-8/h2-6H2,1H3

Upstream product

• 110-91-8 morpholine 
• 78-95-5 chloroacetone 
• 116-09-6 hydroxy-2-propanone 
• 2684-62-0 diazoacetone 
• 1833-53-0 2-(Trimethylsilyloxy)propene 
• 56-81-5 glycerol 
• 107-19-7 propargyl alcohol 
• 124-38-9 carbon dioxide 

Downstream Products

• 80305-02-8 (E)-4-(3-Hydroxy-4-methoxy-phenyl)-1-morpholin-4-yl-but-3-en-2-one 
• 66596-42-7 (E)-4-Benzo[1,3]dioxol-5-yl-1-morpholin-4-yl-but-3-en-2-one 
• 80304-97-8 (E)-1-Morpholin-4-yl-4-(2,4,6-trimethoxy-phenyl)-but-3-en-2-one 
• 80304-92-3 (E)-4-(4-Allyloxy-phenyl)-1-morpholin-4-yl-but-3-en-2-one 
• 80304-91-2 (E)-1-Morpholin-4-yl-4-(4-prop-2-ynyloxy-phenyl)-but-3-en-2-one 
• 80305-03-9 (E)-1-Morpholin-4-yl-4-p-tolyl-but-3-en-2-one 
• 80305-00-6 (E)-1-Morpholin-4-yl-4-phenyl-but-3-en-2-one 
• 80304-90-1 (E)-4-(4-Hydroxy-phenyl)-1-morpholin-4-yl-but-3-en-2-one 
• 80304-87-6 (methoxy-4 phenyl)-1 N morpholino-4 butene-1 one-3 
• 80305-01-7 (E)-4-(4-Hydroxy-3-methoxy-phenyl)-1-morpholin-4-yl-but-3-en-2-one 
• 80304-95-6 (E)-4-(3,4-Dimethoxy-phenyl)-1-morpholin-4-yl-but-3-en-2-one 
• 80304-94-5 (E)-4-(2,5-Dimethoxy-phenyl)-1-morpholin-4-yl-but-3-en-2-one 
• 80304-98-9 (E)-4-(2-Methoxy-phenyl)-1-morpholin-4-yl-but-3-en-2-one 
• 80304-93-4 (E)-4-(2,4-Dimethoxy-phenyl)-1-morpholin-4-yl-but-3-en-2-one 

Relevant articles and documents

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Glycerol as a Building Block for Prochiral Aminoketone, N-Formamide, and N-Methyl Amine Synthesis

Prochiral aminoketones are key intermediates for the synthesis of optically active amino alcohols, and glycerol is one of the main biomass-based alcohols available in industry. In this work, glycerol was catalytically activated and purposefully converted with amines to generate highly valuable prochiral aminoketones, as well as N-formamides and N-methyl amines, over CuNiAlOx catalyst. The catalyst structure can be anticipated as nano-Ni species on or in CuAlOx via the formation of nano- Cu?Ni alloy particles. This concept may present a novel and valuable methodology for glycerol utilization.

Retro-aldol and redox reactions of Amadori compounds: Mechanistic studies with variously labeled D-[13C]glucose

Oxidation-reduction reactions necessary to justify many of the products observed in Maillard model systems are usually attributed to molecular oxygen and the so-called reductons. The proline specific 1-(1′-pyrrolidinyl)-2-propanone and 1-(1′-pyrrolidinyl)-2-butanone are such compounds that require reduction steps to justify their formation. Experimental evidence using glucose separately labeled at 13C1, 13C2, 13C3, 13C4, 13C5, and 13C6 indicates that 1-(1′-pyrrolidinyl)-2-propanone is formed by two related pathways, initiated by a retro-aldol cleavage of proline Amadori compound at C3-C4, and 1-(1′-pyrrolidinyl)-2-butanone is formed by three pathways, one initiated by a retro-aldol reaction at C2-C3 of the 1-(prolino)-1-deoxy-4-hexosulose (an isomer of Amadori product formed by carbonyl migration) and two others by similar retro-aldol reactions at C4-C5 from both 3-deoxyglucosone and 1-(prolino)-1,4-dideoxy-2,3-hexodiulose. All of the proposed mechanisms require reduction steps for the formation of the target compounds. Model studies have indicated that reductions in Maillard systems can be effected by three pathways: through hydride transfer from formic acid; through cyclic dimerization of α-hydroxy carbonyl compounds followed by electrocyclic ring opening to produce oxidation/reduction products; and by disproportionation of enediols with α-dicarbonyl compounds through double proton transfer.