67060-92-8

Upstream product

• 120-72-9 indole 
• 925-90-6 ethylmagnesium bromide 
• 15224-25-6 3-benzoylindole 
• 98-88-4 benzoyl chloride 
• 93-97-0 benzoic acid anhydride 
• 576-15-8 N-acetylindole 
• 39203-20-8 methyl 1H-indole-1-carboxylate 
• 31271-90-6 1-(p-toluenesulfonyl)-1H-indole 
• 1496-76-0 N-benzoylindole 
• 698-16-8 benzohydroximoyl chloride 
• 611-73-4 Benzoylformic acid 
• 91476-96-9 3-Phenyl-8-(toluene-4-sulfonyl)-8,8a-dihydro-3aH-isoxazolo[5,4-b]indole 
• 91477-17-7 phenyl(1-tosyl-1H-indol-3-yl)methanone 
• 91476-93-6 Phenyl-(3-phenyl-3a,8a-dihydro-isoxazolo[5,4-b]indol-8-yl)-methanone 

Relevant academic research and scientific papers

Room temperature palladium-catalyzed decarboxylative acyl/aroylation using [Fe(III)(EDTA)(η2-O2)]3- as oxidant at biological pH

The purple-coloured iron peroxo complex [Fe(III)EDTA(η2- O2)]3- as a novel reagent system for Pd-catalyzed decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids at room temperature in aqueous media has been realized. This reaction provides an effective access to ortho-acylacetanilides under mild conditions. Copyright

Formation of indole nucleus via intramolecular cyclization of aminophenylpropenyltriphenylphosphonium salts with one-carbon degradation

Treatment of 3-(2-aminophenyl)-2-propenyltriphenylphosphonium bromide with acid anhydride and tertiary amine affords 1,3-diacylindoles in yields ranging from 22 to 64%. A plausible mechanism of this new cyclization reaction is described.

Acylation, cyanoethylation and alkylation of methyl and phenyl indolylmagnesium salts: Influence of the substituents on the C- and N- reaction products

Analysis of the influence of the substitution on indolylmagnesium salts in the reaction with benzoyl chloride, acrylonitrile and methyl iodide, giving the C- and N-derivatives, have been carried out. The yield in the C- and N-product depends upon the electronic character and position of the substituent (methyl or phenyl) on the indole ring and of the ethereal solvent as well as the concentration and molar ratio of the reagents. The 2- or 3- phenyl substituted indolylmagnesium salts with acrylonitrile always gave the 1-(2-cyanoethyl)indole derivative.