67069-47-0

Basic information

• Product Name: fluopsin C
• CAS NO: 67069-47-0
• Molecular Weight: 243.798
• Mol File: 67069-47-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: fluopsin C(CAS DataBase Reference)
• NIST Chemistry Reference: fluopsin C(67069-47-0)
• EPA Substance Registry System: fluopsin C(67069-47-0)

Safety Data

• Hazardous Substances Data: 67069-47-0(Hazardous Substances Data)

Downstream Products

• 67069-47-0 fluopsin C 

Relevant articles and documents

Biosynthesis of fluopsin C, a copper-containing antibiotic from Pseudomonas aeruginosa

Metal-binding natural products contribute to metal acquisition and bacterial virulence, but their roles in metal stress response are underexplored. We show that a five-enzyme pathway in Pseudomonas aeruginosa synthesizes a small-molecule copper complex, fluopsin C, in response to elevated copper concentrations. Fluopsin C is a broad-spectrum antibiotic that contains a copper ion chelated by two minimal thiohydroxamates. Biosynthesis of the thiohydroxamate begins with cysteine and requires two lyases, two iron-dependent enzymes, and a methyltransferase. The iron-dependent enzymes remove the carboxyl group and the a carbon from cysteine through decarboxylation, N-hydroxylation, and methylene excision. Conservation of the pathway in P. aeruginosa and other bacteria suggests a common role for fluopsin C in the copper stress response, which involves fusing copper into an antibiotic against other microbes.