67089-07-0

Upstream product

• 3839-35-8 4-methylbenzenesulfonic acid n-hexylester 
• 54494-87-0 resorcinol; sodium-compound 
• 122710-28-5 1-Allyloxy-3-hexyloxy-benzene 
• 111-25-1 1-bromo-hexane 
• 108-46-3 recorcinol 
• 408538-95-4 3-Hexanoyloxy-phenol 
• 7487-94-7 mercury (II) chloride 
• 142-62-1 hexanoic acid 
• 7440-66-6 zinc 

Downstream Products

• 885620-28-0 5-(hexyloxy)-2-nitrophenol 
• 67089-10-5 1-(4-bromobutoxy)-3-(hexyloxy)benzene 

Relevant academic research and scientific papers

Kinetically controlled diastereoselective synthesis of CPS124, a carnitine monothiophosphate

An expedient synthesis of CPS124 (1) is described using the diastereoselective reaction of the in situ generated dichlorophosphite 6 with L-carnitine tetrafluoroborate salt 7 under kinetic control as the key step. Alkylations of resorcinol 2 and its benzoate 13 are discussed. The use of α-cellulose as a support for solids that are difficult to filter or low melting is presented.

Phthalocyanine-based discotic liquid crystals switching from a molten alkyl chain type to a flying-seed-like type

We have synthesised a series of phthalocyanine-based discotic liquid crystals, (m-CnOPhO)8PcCu (n = 1-20: 2a-o), and investigated their mesomorphism by using a polarizing optical microscope (POM), a differential scanning calorimeter (DSC) and a temperature-dependent small angle X-ray diffractometer. We found that each of the derivatives 2a-o shows mesomorphism. However, the mesomorphism of the (m-CnOPhO)8PcCu derivatives strongly depends on the alkoxy chain length (n). The mesomorphism of the short chain-substituted derivatives 2a-e for n = 1-5 is a flying-seed-like type induced by flip-flop of the peripheral bulky substituents, whereas the mesomorphism of the long chain-substituted derivatives 2j-o for n = 10-20 is a conventional molten alkyl chain type induced by melting of the long alkyl chains. The moderately long chain derivatives (2f-i) for n = 6-9 in between show both types of mesophases. The detailed temperature-dependent X-ray diffraction measurements were carried out for three representative derivatives, 2b (n = 2 for n = 1-5), 2h (n = 8 for n = 6-9), and 2o (n = 20 for n = 10-20). As a result, we revealed that the Colro(P2m) mesophase in 2b (n = 2) gave a halo denoted as Haloarom. at d ? 5.2 ? due to flip-flop of the bulky aromatic substituents, and that the Colho mesophase in 2o (n = 20) gave a halo denoted as Haloalkyl at d ? 4.6-4.8 ? due to melting of the long alkyl chains. Therefore, we can distinguish the type of mesophase from Haloarom. and Haloalkyl. Very interestingly, the (m-C8OPhO)8PcCu (2h) derivative having moderately long alkyl chains gave Haloalkyl at about 4.8 ? in the lower temperature mesophase of Colho, but Haloarom. at about 5.2 ? in the higher temperature mesophase of Colro(P21/a). This means that melting of the alkyl chains induces the Colho phase in the lower temperature region, but that flip-flop of the bulky aromatic substituents induces the Colro(P21/a) phase in the higher temperature region. This unusual reverse phase transition sequence from a higher symmetry of the Colh mesophase to a lower symmetry of the Colr mesophase on a heating stage is attributable to such a unique stepwise melting of these two different types of substituents. To the best of our knowledge, this mesogen (2h) is the first example switching mesomorphism from the molten alkyl chain type to the flying-seed-like type in a discotic liquid crystal.

AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC AND ANTICANCER ACTIVITY

Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

Aminocarnitine ureidic derivatives as inhibitors of carnitine palmitoyltransferase I

(Chemical Equation Presented) Aminocarnitine ureidic derivatives were synthesized and evaluated as liverisoform-selective carnitine palmitoyltransferase (CPT) I inhibitors. The most interesting molecule identified (3), the corresponding phosphonium analog

DERIVATIVES OF 4-TRIMETHYLAMMONIUM-3-AMINOBUTYRATE AND 4-TRIMETHYLPHOSPHONIUM-3-AMINOBUTYRATE AS CPT-INHIBITORS

The invention provides a new class of compounds capable of inhibiting carnitine palmitoyl transferase (CPT) having formula (I). The invention also relates to pharmaceutical compositions, which comprise at least one new compound according to the invention,

Synthesis and properties of 2-phenylbenzoxazole-based luminophores for in situ photopolymerized liquid-crystal films

We report the synthesis of a series of blue-emitting 2-phenylbenzoxazoles (PBOs) substituted at either the 5- or 6-position of the benzoxazole ring and the para-position of the phenyl substituent. The thermal and optical properties of the materials can be rationalized in terms of the position of the substituent at the benzoxazole moiety and the electron-withdrawing or electron-donating character of the substituents. From the results, we conclude that the combination of an electron-donating substituent at the benzoxazole fragment and an electron-withdrawing one at the phenyl fragment has a more marked effect on the electronic properties of the aromatic PBO core than other possibilities. This particular combination gives luminophores that are suitable for optical applications on the basis of their high emission efficiency and photostability. In view of that, oriented films were prepared by in situ polymerization of a mixture of a liquid crystalline direactive matrix containing 5% (w/w) of the luminophore. The films exhibit linearly polarized emission.

Selective etherification of polyhydroxybenzenes using PEG 200 as solvent or cosolvent

The monoalkylation of hydroquinone is performed using PEG 200 as a solvent or a cosolvent.The effect on the selectivity of the base strength, the temperature, and the percentage of cosolvent are discussed.The substituted phenols were found to behave differently upon etherification.When a carboxylic function is present in the ring, the hydroxybenzoic acids were selectively etherified using pure PEG and sodium hydroxyde as a base.Substituted diphenols were selectively etherified using a mixture of PEG and dioxan and potassium hydrogencarbonate as a base.Keywords - etherification / selectivity / polyhydroxybenzenes / polyethylene glycol

Skin depigmental agent

A skin depigmental agent characterized by comprising a resorcinol derivative having a linear alkyl group is provided.

MODIFICATION OF PHOTOCHEMICAL REACTIVITY BY CYCLODEXTRIN COMPLEXATION: SELECTIVITY IN PHOTO-CLAISEN REARRANGEMENT

Photorearrangements of meta-alkoxyphenylallyl ethers 1-5 in ethanol, in water and as complexes of α and β-cyclodextrins have been investigated.The ratio of the two ortho rearrangement products was dependent both on the lenght of the alkoxy substituent and on that of the host cavity suggesting that, subtle and rationale engineering manipulation is required to achieve exclusive obtention of only one ortho isomer.It is speculated that α-cyclodextrin provides a "tight fit" while β-cyclodextrin offers a "loose fit".This tightness of binding is suggested to be responsible for the selectivity among the ortho isomers with α-cyclodextrin as the host.Further, the results indicate that "loose cavity" can be tighttened by incorporating a "molecular spacer" such as a long hydrocarbon chain as an intramolecular appendix.