3839-35-8

Usage

Uses

Used in Pharmaceutical Synthesis:
P-TOLUENESULFONIC ACID N-HEXYL ESTER is used as a reactant in the synthesis of 7-bromo-5-(2''-chlorophenyl)-3-hydroxy-1-methyl-1,2-dihydro-3H-1,4-benzodiazepin-2-one 1 and 7-bromo-5-(2''-chloro)phenyl-1-hexyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepin-2,3-dione. These compounds are important in the development of pharmaceuticals, particularly those targeting central nervous system disorders and other therapeutic applications.
Used in Carbazate Synthesis:
In the chemical industry, P-TOLUENESULFONIC ACID N-HEXYL ESTER is also utilized in the synthesis of carbazates. Carbazates are a class of compounds that have potential applications in various fields, including as intermediates for the production of pharmaceuticals, agrochemicals, and other specialty chemicals. The use of Hexyl p-Toluenesulfonate in this process highlights its versatility and importance in the synthesis of a wide range of organic compounds.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 111-27-3 hexan-1-ol 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 94957-45-6 n-butylethynyl tosylate 
• 7182-86-7 tetrabutylammonium p-toluenesulfonate 
• 638-45-9 1-Iodohexane 
• 27126-76-7 [hydroxy(tosyloxy)iodo]benzene 
• 6095-42-7 tri-n-hexyl phosphite 
• 104-15-4 toluene-4-sulfonic acid 
• 142-92-7 1-hexyl acetate 
• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 1680206-12-5 Grushin’s reagent 
• 6926-45-0 1-azidohexane 
• 111-25-1 1-bromo-hexane 

Downstream Products

• 67685-82-9 1,3-bis(hexyloxy)benzene 
• 67089-07-0 n-hexyl resorcinol 
• 31189-03-4 2-(hexyloxy)phenol 
• 67285-54-5 1-(hexyloxy)-2-nitrobenzene 
• 67399-93-3 1,4-dihexyloxybenzene 
• 18979-55-0 4-(hexyloxy)phenol 
• 373-14-8 1-fluorohexane 
• 75941-33-2 2,3-dicyanohydroquinone monohexyl ether 
• 111-27-3 hexan-1-ol 
• 59693-91-3 n-Hexyl-p-chlorphenylsulfid 
• 885620-30-4 hexyl 3-hydroxy-4-nitrobenzoate 
• 137615-41-9 (+)-4-benzyloxy-1-(1-hexyloxy-2,2,2-trifluoroethyl)benzene 
• 172154-63-1 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-6-n-hexyloxypurine 
• 119838-77-6 (+)-benzyl 4-(1hexyloxyethyl)benzoate 

Relevant academic research and scientific papers

Synthesis of polyfluorinated ethers

Procedures for preparing polyfluorinated ethers H(CF2CF 2)nCH2OR by alkylation of the corresponding telomeric alcohols H(CF2CF2)nCH2OH (n = 1-3) with alkyl halides and alkyl tosylates were examined.

A preparing method of diethylamino hydroxybenzoyl hexylbenzoate

The present invention relates to a method for the preparation of diethylamino hydroxybenzoyl hexyl benzoate. Specifically, the present invention relates to a method for preparing diethylamino hydroxybenzoyl hexyl benzoate which is easy to manufacture and commercially available in mass production, and diethylamino hydroxybenzoyl hexyl benzoate crystalline particles prepared thereby. According to the present invention, diethylamino hydroxybenzoyl hexyl benzoate crystalline particles having excellent UV blocking effect can be obtained in a stable and high yield.COPYRIGHT KIPO 2020

Combinatorial discovery of thermoresponsive cycloammonium ionic liquids

This work demonstrated, for the first time, the combinatorial discovery and rational identification of small-molecule cycloammonium-based thermoresponsive ionic liquids that exhibit LCST phase transition and carry attractiveTcvalues in water.

Method for preparing N,N-Dimethylaniline compound through alkylation of alkyl tosylate

The invention provides a method for preparing a N,N-Dimethylaniline compound through alkylation of alkyl tosylate, and belongs to the technical field of organic synthesis. According to the method, paratoluensulfonyl chloride and fatty alcohol serve as raw materials, pyridine serves as an acid-binding agent, and the alkyl tosylate is generated; the alkyl tosylate as an alkylation reagent and an aniline compound are alkylated under the alkaline condition to obtain the N,N-Dimethylaniline compound. The method is implemented at normal pressure, the operation is simple, no waste acid is generated,the yield and the purity are high, and the method is suitable for industrial and scaled production.

Ionic liquid brush as an efficient and reusable heterogeneous catalytic assembly for the tosylation of phenols and alcohols in neat water

A very efficient and reusable heterogeneous ionic liquid brush assembly was developed. The catalyst exhibits high catalytic activity for the tosylation of phenols and alcohols in neat water. Moreover, the catalyst shows outstanding stability and reusability, and it can be simply and effectively recovered and reused five times without noticeable loss of catalytic activity.

Trifluoromethylation of Alkyl Radicals in Aqueous Solution

The copper-mediated trifluoromethylation of alkyl radicals is described. The combination of Et3SiH and K2S2O8 initiates the radical reactions of alkyl bromides or iodides with BPyCu(CF3)3 (BPy = 2,2′-bipyridine) in aqueous acetone at room temperature to afford the corresponding trifluoromethylation products in good yield. The protocol is applicable to various primary and secondary alkyl halides and exhibits wide functional group compatibility. A mechanism involving trifluoromethyl group transfer from Cu(II)-CF3 intermediates to alkyl radicals is proposed.

Hexyl triazabutadiene as a potent alkylating agent

Alkyl diazonium ions are among the most reactive alkylating agents in the synthetic chemists’ arsenal. That said, there are precious few methods by which one can selectively and safely utilize this chemistry. Herein, we show the use of a bench stable hexyl triazabutadiene as a source of reactive diazonium ions that undergo substitution chemistry with weak nucleophiles, such as carboxylates and even sulfonates. In the absence of a nucleophile, elimination was observed to occur. To overcome issues stemming from side-product inhibition of the reaction, we show that the triazabutadiene can be pre-activated with tosyl isocyanate.

A [...] analogs, its preparation process and its application

The invention discloses a largazole analogue which contains alkyl disulfide side chains and is represented by formula I, and a preparation method and applications thereof. The largazole analogue possesses relatively high antineoplastic activity and selectivity, can be used for development of antitumor drugs. Raw materials of the largazole analogue are cheap and easily available; and the preparation method is simple, and is a method suitable for industrialization. R in formula represents an alkyl group containing 1 to 8 carbon atoms.

Synthesis of structural analogues of hexadecylphosphocholine and their antineoplastic, antimicrobial and amoebicidal activity

Twelve derivatives of hexadecylphosphocholine (miltefosine) were synthesized to determine how the position and length of the alkyl chain within the molecule influence their biological activities. The prepared alkylphosphocholines have the same molecular formula as miltefosine. Activity of the compounds was studied against a spectrum of tumour cells, two species of protozoans, bacteria and yeast. Antitumour efficacy of some alkylphosphocholines measured up on MCF-7, A2780, HUT-78 and THP-1 cell lines was higher than that of miltefosine. The compounds showed antiprotozoal activity against Acanthamoeba lugdunensis and Acanthamoeba quina. Some of them also possess fungicidal activity against Candida albicans equal to miltefosine. No antibacterial activity was observed against Staphylococcus aureus and Escherichia coli. A difference in position of a long hydrocarbon chain within the structure with maximum efficacy was observed for antitumour, antiprotozoal and antifungal activity.

Iodine-induced synthesis of sulfonate esters from sodium sulfinates and phenols under mild conditions

An iodine-induced synthesis of sulfonate esters via cross-coupling reactions of sodium sulfinates with phenols is reported. This synthetic route is low-cost, facile, green and efficient, and could afford the target products with good to excellent yields u