67095-88-9

Basic information

• Product Name: N,N-diethyl-4-methylbenzimidamide
• Synonyms: N,N-diethyl-4-methylbenzimidamide
• CAS NO: 67095-88-9
• Molecular Weight: 190.288
• Mol File: 67095-88-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-4-methylbenzimidamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-4-methylbenzimidamide(67095-88-9)
• EPA Substance Registry System: N,N-diethyl-4-methylbenzimidamide(67095-88-9)

Safety Data

• Hazardous Substances Data: 67095-88-9(Hazardous Substances Data)

Upstream product

• 104-85-8 para-methylbenzonitrile 
• 109-89-7 diethylamine 

Downstream Products

• 23275-54-9 5-(4-tolyl)-1,2,4-oxadiazol-3-amine 
• 1418139-63-5 N,5-di(4-tolyl)-1,2,4-oxadiazol-3-amine 
• 1418139-62-4 N-(4-methoxyphenyl)-5-(4-tolyl)-1,2,4-oxadiazol-3-amine 

Relevant articles and documents

A diversified assembly of 1,2,4-oxadiazol-3-amines: Metallic thiophile catalyzed chemoselective one-pot reaction of aryl isothiocyanates, amidines/guanidines, and hydroxylamine

An efficient one-pot synthesis of 1,2,4-oxadiazol-3-amines from simple starting materials, isothiocyanates, amidines/guanidines, and hydroxylamine, is described. The reaction is facilitated by metallic-thiophile-assisted desulfurization of in situ formed amidino- or guanidinothiourea to give chemoselectively N-hydroxyguanidine intermediates that give exclusively various 1,2,4-oxadiazol-3-amines in good to excellent yields. The reaction mechanistic pathway may proceed through an intramolecular 5-exo-trig cyclization.