67099-40-5

Usage

Uses

Used in Organic Synthesis:
3,3-dimethylpent-4-ynoic acid is utilized as a building block in organic synthesis for the creation of various chemical compounds. Its unique structure allows for versatile reactions and the formation of a wide range of products.
Used in Chemical Research:
In the field of chemical research, 3,3-dimethylpent-4-ynoic acid serves as a valuable compound for studying reaction mechanisms, exploring new synthetic pathways, and understanding the properties of similar molecules.
Used in Pharmaceutical Industry:
3,3-dimethylpent-4-ynoic acid is employed as an intermediate in the development of pharmaceuticals. Its specific functional groups and structural features make it a promising candidate for the synthesis of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3,3-dimethylpent-4-ynoic acid is used as a precursor for the synthesis of various agrochemicals, such as pesticides and herbicides. Its unique structure contributes to the development of effective and targeted products for agricultural use.

Upstream product

• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 105-53-3 diethyl malonate 
• 66476-86-6 ethyl 3,3-dimethyl-4-pentynoate 
• 2231-66-5 2,2-dimethyl-5-(propan-2-ylidene)-1,3-dioxane-4,6-dione 

Downstream Products

• 65371-43-9 3,3-Dimethyl-4-penten-4-olide 
• 94500-37-5 tert-Butyl-diphenyl-(4,4,7,7-tetramethyl-4,7-dihydro-oxepin-2-yloxy)-silane 
• 94500-33-1 (+/-)-tert-butyldiphenylsilyl cis-chrysanthemate 
• 2935-23-1 cis-Chrysanthemic acid 
• 29444-03-9 (+)-jatrophone 
• 167390-32-1 N-benzyl-4,4-dimethyl-5-methylene-2-pyrrolidinone 
• 167390-49-0 N-benzyl-3,3-dimethyl-4-pentynamide 

Relevant academic research and scientific papers

A highly active diradical cobalt(iii) catalyst for the cycloisomerization of alkynoic acids

The first cobalt-catalysed cycloisomerisation of alkynoic acids is reported, thanks to the design of a well-defined diradical cobalt(iii) catalyst, in the absence of any additives. The high efficiency, regioselectivity and chemoselectivity are comparable to those of noble metal-based systems. The unique reactivity might be attributed to second coordination sphere effects.

Rapid Access to Thiolactone Derivatives through Radical-Mediated Acyl Thiol-Ene and Acyl Thiol-Yne Cyclization

A new synthetic approach to thiolactones that employs an efficient acyl thiol-ene (ATE) or acyl thiol-yne (ATY) cyclization to convert unsaturated thiocarboxylic acid derivatives into thiolactones under very mild conditions is described. The high overall yields, fast kinetics, high diastereoselectivity, excellent regiocontrol, and broad substrate scope of these reaction processes render this a very useful approach for diversity-oriented synthesis and drug discovery efforts. A detailed computational rationale is provided for the observed regiocontrol.

STEREOSPECIFIC SYNTHESIS OF CIS-2-ALKENYLCYCLOPROPANE CARBOXYLIC ACIDS; A TOTAL SYNTHESIS OF (+/-)-CIS-CHRYSANTHEMIC ACID

A stereospecific route to cis-2,2-dimethyl-3-alkenyl-cyclopropanecarboxylic Acids is illustrated by a total synthesis of (+/-)-cis-Chrysanthemic Acid (11).The key step consists of an alicyclic Claisen rearrangement of O-silyl enolates derived from appropriately substituted (Z)-4-hexen-6-olides .