671-89-6

Basic information

• Product Name: 4-AMINO-6-CHLORO-BENZENE-1,3-DISULFONYL DICHLORIDE
• Synonyms: 4-amino-6-chlorobenzene-1,3-di(sulphonyl chloride);4-AMINO-6-CHLORO-1,3-BENZENEDISULFONYL CHLORIDE;4-Amino-6-chloro-1,3-benzenedisulfonyl;4-azanyl-6-chloro-benzene-1,3-disulfonyl chloride;4-Amino-6-chloro-1,3-benzenedisulfonyl Dichloride;5-Chloro-2,4-dichlorosulfonylaniline;5-Chloroaniline-2,4-disulfonyl Dichloride;4-AMINO-6CHLOROBENZENE 1,3-DISULFONYL CHLORIDE
• CAS NO: 671-89-6
• Molecular Formula: C₆H₄Cl₃NO₄S₂
• Molecular Weight: 324.59
• EINECS: 211-586-4
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 671-89-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 130-132 °C
• Boiling Point: 474.2 ºC at 760 mmHg
• Flash Point: 240.6 ºC
• Appearance: /
• Density: 1.834 g/cm³
• Vapor Pressure: 3.7E-09mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: 2-8°C
• PKA: -5.05±0.16(Predicted)
• CAS DataBase Reference: 4-AMINO-6-CHLORO-BENZENE-1,3-DISULFONYL DICHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-6-CHLORO-BENZENE-1,3-DISULFONYL DICHLORIDE(671-89-6)
• EPA Substance Registry System: 4-AMINO-6-CHLORO-BENZENE-1,3-DISULFONYL DICHLORIDE(671-89-6)

Safety Data

• Hazardous Substances Data: 671-89-6(Hazardous Substances Data)

Usage

Chemical Properties

Brown Solid

Uses

Chlorothiazide intermediate.

InChI:InChI=1/C6H4Cl3NO4S2/c7-3-1-4(10)6(16(9,13)14)2-5(3)15(8,11)12/h1-2H,10H2

Upstream product

• 108-42-9 3-chloro-aniline 

Downstream Products

• 4143-75-3 4-Amino-6-Chloro-3-(Methylaminosulfonyl)Benzenesulfonyl Chloride 
• 37458-91-6 6-Chlor-2-methyl-7-(N-methyl-sulfamoyl)-3,4-dihydro-1,2,4-benzothiadiazin-1,1-dioxid 
• 2880-40-2 2,5'-dichloro-2',4'-disulfamoylacetanilide 
• 101715-19-9 4-Chlor-2-butyrylamino-1.5-bis--benzol 
• 90945-28-1 Buttersaeure-<5-chlor-2,4-bis-(amino-sulfonyl)-anilid> 
• 40642-90-8 4-amino-1,3-benzenedisulfonamide 
• 124110-20-9 5-Chlor-2.4-disulfamoyl-N-palmitoyl-anilin 
• 107623-20-1 4-chloro-6-(4-chloro-benzoylamino)-benzene-1,3-disulfonic acid diamide 
• 91872-64-9 2.4-Di-acetylsulfamoyl-acetanilid 
• 89799-93-9 5.-Chlor-6-Jod-2.4-disulfamoyl-anilin 
• 1049-55-4 4-Chlor-2-acetamino-1.5-bis--benzol 
• 1047-46-7 4-benzoylamino-6-chloro-benzene-1,3-disulfonic acid diamide 
• 1029-80-7 N-Acetyl-5-chlor-anilin-disulfonsaeure-(2.4)-dichlorid 
• 5250-72-6 4-amino-5,6-dichloro-benzene-1,3-disulfonic acid diamide 

Relevant articles and documents

Mass spectrometric behavior of thiazide-based diuretics after electrospray ionization and collision-induced dissociation.

The mass spectrometric behavior of 21 thiazide-based compounds after electrospray ionization in the negative ion mode and collision-induced dissociation was investigated on a triple-stage quadrupole mass spectrometer. The mass spectra show individual and common fragmentation patterns, the generations of which are discussed based on comparable molecular structures of commercially available substances and the synthesis of unlabeled, deuterated, and 15N-labeled analogues. The synthesis of deuterated thiazides is perfomed by condensation of 4-amino-6-chloro-1,3-benzenedisulfonamide with appropriately labeled aldehydes, while the introduction of 15N into the sulfonamide groups of thiazides was achieved by the synthesis of 4-amino-6-chloro-1,3-benzenedisulfonamide(15N2) from 3-chloroaniline via 4-amino-6-chloro-1,3-benzenedisulfonyl chloride. The most common fragments determined are m/z 269, 205, and 126 for 6-chloro-7-sulfamoyl-3-alkyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxides and m/z 303, 239, and 160 for 6-trifluoromethyl-7-sulfamoyl-3-alkyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxides. Individual fragmentation behaviors were found that mainly depended on the C-3-linked side chain.