67116-18-1

Upstream product

• 828-51-3 1-Adamantanecarboxylic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 4885-02-3 Dichloromethyl methyl ether 
• 780-68-7 1-phenyladamantane 
• 768-90-1 1-Adamantyl bromide 
• 71-43-2 benzene 
• 7131-09-1 1-(4-(bromomethyl)phenyl)adamantane 
• 108-88-3 toluene 
• 89311-74-0 1-(4-Dibromomethyl-phenyl)-adamantane 
• 2245-43-4 4-(1-Adamantyl)bromobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 7131-08-0 (4-(adamantan-1-yl)phenyl)methanol 
• 1459-55-8 4-(1-adamantyl)toluene 
• 768-95-6 1-adamanthanol 

Downstream Products

• 73861-72-0 3-[4-(1-adamantyl)phenyl]propionic acid 

Relevant academic research and scientific papers

Preparation and application of thiosemicarbazone compound

The invention discloses a thiosemicarbazone compound, and biological activity analysis is carried out on the thiosemicarbazone compound. The invention also discloses application of the thiosemicarbazone compound in preparation of antibacterial drugs. According to the invention, important intermediates 6a-6h are synthesized from hydrazine hydrate and react with adamantane benzaldehyde respectivelyto synthesize eight adamantane aromatic aldehyde thiosemicarbazone compounds, the structures of the compounds can be confirmed by infrared, nuclear magnetic hydrogen spectrum, carbon spectrum and massspectrum methods, and the antibacterial activity of the compounds is tested in vitro. The result shows that the compound has a good antibacterial effect on escherichia coli and bacillus subtilis.

Synthesis and antibacterial activity of novel Schiff bases of thiosemicarbazone derivatives with adamantane moiety

Increased bacterial resistance to antibiotics is a major threat to human health, and it is particularly important to develop novel antibiotic drugs. Here, we designed a series of Schiff base thiosemicarbazone derivatives containing an adamantane moiety, and carried out the structural characterization of the compounds and in vitro antibacterial activity tests. Compound 7e was as effective as the commonly used antibiotic ampicillin against the Gram-negative bacterium Escherichia coli, and compound 7g had a good inhibitory effect against Gram-positive Bacillus subtilis. These findings provide data for the development of better thiosemicarbazone antibacterial agents.

Adamantane styrene derivatives, and preparation method and application thereof

The invention discloses adamantane styrene derivatives and analysis of the biological activity of the adamantane styrene derivatives. According to the invention, a synthesized compound retains an adamantane structure, an adamantane ring structure is conne

4-(1-Adamantyl)phenylalkylamines with potential antiproliferative activity

Background: In our previous publications we have described the synthesis of aminosubstituded diaryl adamantanes and their pharmacological evaluation in vitro and in vivo against many cancer cell lines. More recently, we have reported the synthesis of mono

Synthesis of substituted adamantylzinc reagents using a Mg-insertion in the presence of ZnCl2 and further functionalizations

The LiCl-mediated Mg-insertion in the presence of ZnCl2 allows an efficient synthesis of adamantylzinc reagents starting from the corresponding functionalized tertiary bromides. The highly reactive adamantylzinc species readily undergo a broad

PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS

The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.

Palladium-Catalyzed Coupling Reactions of 1-Bromoadamantane with Styrenes and Arenes

The palladium-catalyzed reaction of 1-bromoadamantane (1-Br) with styrene and donor-substituted styrenes gave the corresponding Heck-type coupling products 3a and b, and 5a and b in moderate yields (15-41percent), while the reaction of 1-Br with various arenes 6a-p under palladium catalysis gave the corresponding adamantyl-substituted arenes 7a-p in good to excellent yields (35-98percent). - Keywords: cross-coupling reactions; metal-catalyzed/adamantylation of styrene and alkenes/arylation of 1-bromoadamantane/Heck reaction; palladium catalysis