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Usage

Uses

Used in Pharmaceutical Industry:
2,4(1H,3H)-Quinazolinedione, 3-(2,3-dimethylphenyl)is used as a chemical intermediate for the synthesis of various drugs. Its unique chemical structure and properties make it a promising candidate for the development of new therapeutic agents.
Used in Drug Discovery and Development:
2,4(1H,3H)-Quinazolinedione, 3-(2,3-dimethylphenyl)is used as a potential lead compound in drug discovery and development. Its chemical properties and structure can be further modified and optimized to develop new drugs for the treatment of various medical conditions.

Upstream product

• 84772-24-7 3-(o,m-Dimethylphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydrochinazolin 
• 5100-23-2 2-isocyanatobenzoyl chloride 
• 87-59-2 2,3-Dimethylaniline 
• 118-48-9 isatoic anhydride 
• 1567-04-0 C₁₇H₁₈N₂O₃ 
• 1591-99-7 1-isocyanato-2,3-dimethylbenzene 

Downstream Products

• 94743-20-1 1-(3,3-Dimethyl-2-oxo-1-phenyl-butyl)-3-(2,3-dimethyl-phenyl)-1H-quinazoline-2,4-dione 
• 94743-21-2 1-(1-Benzyl-3,3-dimethyl-2-oxo-butyl)-3-(2,3-dimethyl-phenyl)-1H-quinazoline-2,4-dione 
• 94743-22-3 1-(3,3-Dimethyl-2-oxo-1-phenethyl-butyl)-3-(2,3-dimethyl-phenyl)-1H-quinazoline-2,4-dione 
• 94743-23-4 1-[3,3-Dimethyl-2-oxo-1-(3-phenyl-propyl)-butyl]-3-(2,3-dimethyl-phenyl)-1H-quinazoline-2,4-dione 
• 94743-24-5 3-(2,3-Dimethyl-phenyl)-1-[1-(2,2-diphenyl-ethyl)-3,3-dimethyl-2-oxo-butyl]-1H-quinazoline-2,4-dione 
• 869716-01-8 2-chloro-3-(2,3-dimethylphenyl)quinazoline-4(3H)-one 

Relevant academic research and scientific papers

Palladium(0)-catalyzed carbon-Hydrogen bond functionalization for the synthesis of indoloquinazolinones

The indoloquinazolinone ring system has attracted considerable attention as a pharmacophore, because it shows various biological activities. The reported synthetic methods for the compound are simple and direct, but are not effective for the direct synthesis of indoloquinazolinone with a methylene group at the C-6 position. A palladium(0)-catalyzed cyclization of chloroquinazolinone via C-H functionalization was developed for a concise synthesis of indoloquinazolinone derivatives. The presence of a substituent at the C-6 position is important for obtaining the product in good yield. The conformation of the reaction intermediate, in particular the N-C-Pd bond angle, is important for the regioselectivity of the reaction.

Synthese de tertiobutylcetones α-azotees de type =N-C(R1)(R2)-CO-C(CH3)3

The α-nitrogen-ketones 2, 3 and 4 were prepared from α-bromoketones.These were synthesized by the bromination of the ketones which had been obtained by the pinacolone or benzyltertiobutylketone alkylation from the corresponding halo-derivatives.We have observed that the bromination of the ketones depends to some extent upon the nature of these compounds.