869716-01-8

Basic information

• Product Name: 2-chloro-3-(2,3-dimethylphenyl)quinazoline-4(3H)-one
• CAS NO: 869716-01-8
• Molecular Weight: 284.745
• Mol File: 869716-01-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-3-(2,3-dimethylphenyl)quinazoline-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-(2,3-dimethylphenyl)quinazoline-4(3H)-one(869716-01-8)
• EPA Substance Registry System: 2-chloro-3-(2,3-dimethylphenyl)quinazoline-4(3H)-one(869716-01-8)

Safety Data

• Hazardous Substances Data: 869716-01-8(Hazardous Substances Data)

Upstream product

• 1567-04-0 C₁₇H₁₈N₂O₃ 
• 1591-99-7 1-isocyanato-2,3-dimethylbenzene 
• 87-59-2 2,3-Dimethylaniline 
• 67116-97-6 3-(2,3-dimethylphenyl)quinazoline-2,4(1H,3H)-dione 

Relevant articles and documents

Palladium(0)-catalyzed carbon-Hydrogen bond functionalization for the synthesis of indoloquinazolinones

The indoloquinazolinone ring system has attracted considerable attention as a pharmacophore, because it shows various biological activities. The reported synthetic methods for the compound are simple and direct, but are not effective for the direct synthesis of indoloquinazolinone with a methylene group at the C-6 position. A palladium(0)-catalyzed cyclization of chloroquinazolinone via C-H functionalization was developed for a concise synthesis of indoloquinazolinone derivatives. The presence of a substituent at the C-6 position is important for obtaining the product in good yield. The conformation of the reaction intermediate, in particular the N-C-Pd bond angle, is important for the regioselectivity of the reaction.