67118-32-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-OXOPYRROLIDIN-1-YL)PROPANOIC ACID is used as an M. tuberculosis α-glucan branching enzyme inhibitor for its potential to target and disrupt the biosynthesis of the mycobacterial cell wall, leading to the inhibition of Mycobacterium tuberculosis growth and proliferation. This application could contribute to the development of novel antimycobacterial drugs to combat drug-resistant tuberculosis.

InChI:InChI=1/C7H11NO3/c1-5(7(10)11)8-4-2-3-6(8)9/h5H,2-4H2,1H3,(H,10,11)

Upstream product

• 535-11-5 Ethyl 2-bromopropionate 
• 616-45-5 2-pyrrolidinon 
• 68117-12-4 alpha-methyl-2-oxo-1-pyrrolidineacetonitrile 

Downstream Products

• 13712-60-2 6,7-dicarbomethoxy-2,3-dihydro-5-methyl-1H-pyrrolizine 
• 1257264-17-7 N-(4-Amino-4'-fluorobiphenyl-3-yl)-3-fluoro-4-[2-(2-oxo-pyrrolidin-1-yl)-propionylamino]-benzamide 

Relevant academic research and scientific papers

1,3-Dipolar cycloadditions of new mesoionic compounds. Synthesis of 1H-pyrrolo[1,2-c]thiazoles, pyrrolizines and 5,6,7,8-tetrahydroindolizines

We studied the 1,3-dipolar cycloaddition reactions between alkyne dipolarophiles and the new mesoionic compounds 2H,5H,7H-thiazolo[4,3-b]oxazol-2-one (12), 2H,5H,7H-pyrrolo[2,1-b]oxazol-2-one (13) and 2H,5H,7H-oxazolo[3,2-a]pyridin-2-one (14). These 1,3-dipoles were prepared in situ by means of cyclodehydration with acetic anhydride of the corresponding α-substituted 4-oxo-3-thiazolidine- (9), 2-oxo-1-pyrrolidine- (10) and 2-oxo-1-piperidineacetic acids (11). The cycloaddition reactions with alkyne dipolarophiles afforded single 1H-pyrrolo[1,2-c]thiazole, pyrrolizine and 5,6,7,8-tetrahydroindolizine derivatives, or a mixture of the two possible regioisomers, depending on whether symmetrical or unsymmetrical alkynes.

Endothelin antagonists

A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.