67129-01-5Relevant academic research and scientific papers
SYNTHESIS OF QUINONOID 6-METHYL AND 6,7-DIMETHYLDIHYDROPTERINS
Matsuura, Sadao,Sugimoto, Takashi,Murata, Shizuaki
, p. 4003 - 4004 (1985)
Quinonoid 6-methyl and 6,7-dimethylpterins were synthesized by the chemical oxidation.Some of their properties are described.
Lipophilic 5,6,7,8-tetrahydropterin substrates for phenylalanine hydroxylase (monkey brain), tryptophan hydroxylase (rat brain) and tyrosine hydroxylase (rat brain)
Armarego, Wilfred L. F.,Taguchi, Hiroyasu,Cotton, Richard G. H.,Battiston, Sandra,Leong, Lillian
, p. 283 - 292 (2007/10/02)
A high yielding unambiguous synthesis of (+/-)-6-alkyl-5,6,7,8-tetrahydropterin 5a-f hydrochlorides starting from ethyl α-isocyanoacetate 1 and the respective alkanoic anhydrides or alkanoyl chlorides in four steps is described.All the six pterins 5a-f that have been synthesised are substrates for mammalian phenylalanine, tryptophan and tyrosine hydroxylases and their activities have been compared with those of natural 6R-tetrahydrobiopterin under similar conditions.The data allowed the choice of 6-n-propyl-5,6,7,8-tetrahydropterin 5c for further studies as a candidate for tetrahydrobiopterin drug therapy.Keywords: (+/-)-6-alkyltetrahydropterinsydroxylase / tryptophan hydroxylase / tyrosine hydroxylase
Pterins Part VI. The Conformation of 5,6,7,8-Tetrahydrofolic Acid and Related Pterins. A 13C Nuclear Magnetic Resonance Study.
Armarego, Wilfred L. F.,Waring, Paul
, p. 3911 - 3926 (2007/10/02)
3J13C-4a,1H-6 and 3J13C-8a,1H-7(ax. and eq.) values were measured from the fully coupled 13C n.m.r. spectra for 5,6,7,8-tetrahydrofolic acid (1), 6-methyl- (2), 5,6-dimethyl- (3), cis-6,7-dimethyl- (4), 6,7,7-trimethyl-5,6,7,8-tetrahydropterin (5) cations, and 5,10-methenyl-5,6,7,8-tetrahydrofolic acid, and were used to estimate the respective ratios 0.7, ca. 1.0, 0.45, 0.5, ca. 1.0, and ca. 1.0 of conformers with an axial H-6 in equilibrium with conformers that have an equatorial H-6.
