67152-53-8

Basic information

• Product Name: cyclo
• CAS NO: 67152-53-8
• Molecular Weight: 341.41
• Mol File: 67152-53-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: cyclo(CAS DataBase Reference)
• NIST Chemistry Reference: cyclo(67152-53-8)
• EPA Substance Registry System: cyclo(67152-53-8)

Safety Data

• Hazardous Substances Data: 67152-53-8(Hazardous Substances Data)

Upstream product

• 87603-12-1 (R)-tert-butyl 2-((S)-2-(methoxycarbonyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate 
• 87603-13-2 (S)-1-((R)-1-(tert-butoxycarbonyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid 
• 37784-17-1 N-(tert-butoxycarbonyl)-D-proline 
• 87603-16-5 Boc-D-Pro-L-Pro-(Bzl)Gly-OTcp 
• 87603-14-3 Boc-D-Pro-L-Pro-(Bzl)Gly-OMe 
• 87603-15-4 Boc-D-Pro-L-Pro-(Bzl)Gly-OH 
• 87603-17-6 HCl*H-D-Pro-L-Pro-(Bzl)Gly-OTcp 

Relevant articles and documents

Peptide Conformations. 27. cyclo-. Synthesis and Conformation in the Crystal and in Solution

270, 300, and 500 MHz 1H and 67.89 MHz 13C NMR spectra of cyclo (1) (Bzl = N-Benzyl) were analyzed with the aid of two-dimensional techniques.A 300 MHz spin echo correlated 1H NMR spectrum (SECSY) yielded the information about coupling pattern.Small long range couplings, which are important for signal assignments, were detected by a special modification of the Jeener spectroscopy.This spectrum is compared with the conventional Jeener spectrum.Carbon- and proton-connectivities result from a 2D-1H-13C shift correlation.Coupling constants and chemical shift values in the proline rings were obtained by iterative simulation both seven-spin systems.The interpretation of the NMR parameters yields a rapid equilibrium between two boat conformations; one of them is strongly preferred (80percent).This conformation was also found in the X-ray crystal structure.