67154-43-2

Basic information

• Product Name: ASISCHEM C66329
• Synonyms: ASISCHEM C66329;1-(3,5-Dimethoxyphenyl)-1H-pyrrole-2,5-dione;1-(3,5-dimethoxyphenyl)-3-pyrroline-2,5-quinone;1-(3,5-dimethoxyphenyl)pyrrole-2,5-dione;Maybridge1_007270;ZINC00102379
• CAS NO: 67154-43-2
• Molecular Formula: C₁₂H₁₁NO₄
• Molecular Weight: 233.22004
• Mol File: 67154-43-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ASISCHEM C66329(CAS DataBase Reference)
• NIST Chemistry Reference: ASISCHEM C66329(67154-43-2)
• EPA Substance Registry System: ASISCHEM C66329(67154-43-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 67154-43-2(Hazardous Substances Data)

Upstream product

• 108-31-6 maleic anhydride 
• 10272-07-8 3.5-dimethoxyaniline 

Downstream Products

• 1332828-56-4 C₁₈H₁₉NO₆ 
• 1354913-08-8 C₁₈H₁₉NO₆ 
• 1431614-81-1 7-(3,5-dimethoxyphenyl)-2,3,7-triazabicyclo[3.3.0]oct-2-ene-6,8-dione 
• 1431614-97-9 6-exo-t-butyl-3-(3,5-dimethoxyphenyl)-6-phenyl-3-azabicyclo-[3.1.0]hexane-2,4-dione 
• 1431614-83-3 C₁₃H₁₃NO₄ 
• 1431614-85-5 C₁₃H₁₃NO₄ 

Relevant articles and documents

Design, synthesis and biochemical evaluation of novel ethanoanthracenes and related compounds to target burkitt’s lymphoma

Lymphomas (cancers of the lymphatic system) account for 12% of malignant diseases worldwide. Burkitt’s lymphoma (BL) is a rare form of non-Hodgkin’s lymphoma in which the cancer starts in the immune B-cells. We report the synthesis and preliminary studies on the antiproliferative activity of a library of 9,10-dihydro-9,10-ethanoanthracene based compounds structurally related to the antidepressant drug maprotiline against BL cell lines MUTU-1 and DG- 75. Structural modifications were achieved by Diels-Alder reaction of the core 9-(2- nitrovinyl)anthracene with number of dienophiles including maleic anhydride, maleimides, acrylonitrile and benzyne. The antiproliferative activity of these compounds was evaluated in BL cell lines EBV? MUTU-1 and EBV+ DG-75 (chemoresistant). The most potent compounds 13j, 15, 16a, 16b, 16c, 16d and 19a displayed IC50 values in the range 0.17–0.38 μM against the BL cell line EBV? MUTU-1 and IC50 values in the range 0.45–0.78 μM against the chemoresistant BL cell line EBV+ DG- 75. Compounds 15, 16b and 16c demonstrated potent ROS dependent apoptotic effects on the BL cell lines which were superior to the control drug taxol and showed minimal cytotoxicity to peripheral blood mononuclear cells (PBMCs). The results suggest that this class of compounds merits further investigation as antiproliferative agents for BL.

Amino Acid Salt Catalyzed Asymmetric Addition Reaction of Acetylacetone to Maleimides and 2-(2-Oxoindolin-3-ylidene)malononitriles

The exploration of catalytic potential of natural amino acid salt in activation of 1,3-dicarbonyls was carried out, in which maleimides and 2-(2-oxoindolin-3-ylidene)malononitriles were found to be good electrophiles and afforded the desired products with excellent yield and moderate optical purity. Control experiments showed that the secondary amino group of barium (S)-prolinate is critical to the catalytic activity as well as enantiocontrol, thus revealed an enamine activation mechanism is possible in the present methodology.