67159-85-7

Basic information

• Product Name: 5-bromo-2,3-dihydro-3,3-dimethylinden-1-one
• Synonyms: 5-bromo-2,3-dihydro-3,3-dimethylinden-1-one;5-bromo-3,3-dimethyl-1-indanone;5-Bromo-3,3-dimethyl-2,3-dihydro-1H-inden-1-one
• CAS NO: 67159-85-7
• Molecular Formula: C11H11BrO
• Molecular Weight: 239.10844
• Mol File: 67159-85-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 123-125 °C(Solv: ethanol (64-17-5))
• Boiling Point: 314.5±41.0 °C(Predicted)
• Appearance: /
• Density: 1.409±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-bromo-2,3-dihydro-3,3-dimethylinden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2,3-dihydro-3,3-dimethylinden-1-one(67159-85-7)
• EPA Substance Registry System: 5-bromo-2,3-dihydro-3,3-dimethylinden-1-one(67159-85-7)

Safety Data

• Hazardous Substances Data: 67159-85-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Upstream product

• 14548-39-1 6-bromoindan-1-one 
• 67159-88-0 6-bromo-2,3-dihydro-1,1-dimethyl-1H-indene 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 25108-58-1 1-bromo-3-isopropenylbenzene 

Downstream Products

• 1396777-58-4 6-bromo-4,4-dimethyl-3,4-dihydroisoquinolin-1(2H)-one 
• 18636-55-0 1,1-dimethyl-1H-indene 

Relevant articles and documents

NOVEL DERIVATIVES HAVING 2,3-DIHYDRO-1H-INDENE OR 2,3-DIHYDROBENZOFURAN MOIETY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

The present invention provides a novel compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

A rhodium(I)-catalysed formal intramolecular C-C/C-H bond metathesis

Phenylcyclobutanes underwent skeletal reorganisation in the presence of Wilkinson's catalyst to afford indanes through a cascade process involving chelation-assisted C-C bond cleavage and intramolecular C-H bond cleavage.

BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description.