671798-72-4

Upstream product

• 21969-32-4 crotylmagnesium chloride 
• 187803-40-3 3,5-bis(tert-butyldimethylsilyloxy)benzaldehyde 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 103929-83-5 methyl 3,5-bis(tert-butyldimethylsilyloxy)benzoate 

Downstream Products

• 671798-94-0 (2R,3S,5S,6R,8S,9S)-8-[3,5-bis(tert-butyldimethylsilyloxy)phenyl]-2-[2-(4-methoxyphenoxy)ethyl]-3,5,9-trimethyl-1,7-dioxaspiro[5.5]undecane 

Relevant academic research and scientific papers

Synthesis of the spiroketal core of integramycin

A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated.

Synthesis of the C16-C35 Fragment of Integramycin Using Olefin Hydroesterification as a Linchpin Reaction

(Matrix presented) The spiroketal unit of the HIV-integrase inhibitor integramycin has been prepared in an efficient and convergent manner. Key steps in this sequence include the use of ruthenium-mediated hydroesterification reactions of homoallylic alcoh