67198-27-0

Basic information

• Product Name: Formamide, N-[2-(dimethylamino)cyclohexyl]-, trans-
• CAS NO: 67198-27-0
• Molecular Formula: C9H18N2O
• Molecular Weight: 170.255
• Mol File: 67198-27-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Formamide, N-[2-(dimethylamino)cyclohexyl]-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-[2-(dimethylamino)cyclohexyl]-, trans-(67198-27-0)
• EPA Substance Registry System: Formamide, N-[2-(dimethylamino)cyclohexyl]-, trans-(67198-27-0)

Safety Data

• Hazardous Substances Data: 67198-27-0(Hazardous Substances Data)

Upstream product

• 67198-21-4 (±)-N,N-dimethyl-trans-1,2-diaminocyclohexane 
• 109-94-4 formic acid ethyl ester 
• 286-20-4 cyclohexane-1,2-epoxide 
• 286-18-0 7-azabicyclo[4.1.0]heptane 
• 4580-81-8 (+/-)-(trans-2-chloro-cyclohexyl)-dimethyl-amine 
• 21651-78-5 trans-2-(N,N-dimethylamino)cyclohexanol 
• 30727-29-8 2-dimethylamino-1-cyclohexanol 

Downstream Products

• 67198-26-9 trans-N,N-dimethyl-N-methyl-1,2-cyclohexanediamine 
• 82657-23-6 trans-N-<2-(dimethylamino)cyclohexyl>-N-methyl-3,4-dichlorobenzamide 
• 67579-11-7 trans-p-chloro-N-<2-(dimethylamino)cyclohexyl>-N-methylbenzamide 
• 67579-34-4 N-((1R,2R)-2-Dimethylamino-cyclohexyl)-3-methoxy-N-methyl-benzamide 
• 98587-46-3 N-((1R,2R)-2-Dimethylamino-cyclohexyl)-N-methyl-4-trifluoromethyl-benzamide 
• 98587-47-4 trans-N-<2-(dimethylamino)cyclohexyl>-p-hydroxy-N-methylbenzamide 
• 67579-77-5 4-Cyano-N-((1R,2R)-2-dimethylamino-cyclohexyl)-N-methyl-benzamide 
• 67579-70-8 trans-N-<2-(dimethylamino)cyclohexyl>-p-methoxy-N-methylbenzamide 
• 98587-45-2 N-((1R,2R)-2-Dimethylamino-cyclohexyl)-N-methyl-4-nitro-benzamide 
• 67197-92-6 2-(3,4-Dichloro-phenyl)-N-((1S,2S)-2-dimethylamino-cyclohexyl)-N-methyl-acetamide 

Relevant articles and documents

Factors affecting binding of trans-N-[2-(methylamino)cyclohexyl]benzamides at the primary morphine receptor

In this paper, we describe the synthesis of a series of trans-N-[2-(methylamine)cyclohexyl]benzamides possessing morphine-like pharmacological properties. The affinity of the compounds for the agonist and antagonist states of the μ opioid receptor has been established by means of an in vitro binding assay. We have investigated the geometry and electronic structure of the molecules using molecular mechanics and an ab initio SCF-MO procedure with FSGO basis sets. Comparison to naloxone reveals properties of possible importance in receptor association. We have considered both the S,S and R,R isomers in the binding model. Statistical analyses imply that three factors play a significant role in binding: membrane-water partitioning, the capacity of the aromatic ring and amine N-substituent to act as electron acceptors, the conformational energy required to attain the binding configuration.