67198-21-4

Basic information

• Product Name: 1,2-Cyclohexanediamine, N,N-dimethyl-, trans-
• Synonyms: 1,2-Cyclohexanediamine, N,N-dimethyl-, trans-;(1R,2R)-rel-N,N-Dimethyl-1,2-cyclohexanediamine;(1R,2R)-2-N,2-N-dimethylcyclohexane-1,2-diamine;trans-N1,N1-Dimethylcyclohexane-1,2-diamine;trans-N,N-Dimethyl-1,2-cyclohexanediamine (Oxaliplatin)
• CAS NO: 67198-21-4
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142
• Mol File: 67198-21-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 91℃ (20 Torr)
• Flash Point: 62.2±13.6 oC
• Appearance: /
• Density: 0.92±0.1 g/cm3 (20 oC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.52±0.70(Predicted)
• CAS DataBase Reference: 1,2-Cyclohexanediamine, N,N-dimethyl-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclohexanediamine, N,N-dimethyl-, trans-(67198-21-4)
• EPA Substance Registry System: 1,2-Cyclohexanediamine, N,N-dimethyl-, trans-(67198-21-4)

Safety Data

• Hazardous Substances Data: 67198-21-4(Hazardous Substances Data)

Usage

Uses

rel-(1R,2R)-N,N-Dimethyl-1,2-cyclohexanediamine is a chiral amine catalysts used in asymmetric direct aldol and Michael addition reactions.

Upstream product

• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 30727-29-8 2-dimethylamino-1-cyclohexanol 
• 286-20-4 cyclohexane-1,2-epoxide 
• 4580-81-8 (+/-)-(trans-2-chloro-cyclohexyl)-dimethyl-amine 
• 21651-78-5 trans-2-(N,N-dimethylamino)cyclohexanol 
• 71172-32-2 trans-1,2-dinitrocyclohexane 
• 286-18-0 7-azabicyclo[4.1.0]heptane 
• 124-40-3 dimethyl amine 
• 152375-95-6 2-dimethylamino-cyclohexanone oxime 

Downstream Products

• 67198-27-0 trans-N-<2-(dimethylamino)cyclohexyl>formamide 
• 38383-49-2 (1R,2R)-bis(dimethylamino)cyclohexane 
• 67197-92-6 2-(3,4-Dichloro-phenyl)-N-((1S,2S)-2-dimethylamino-cyclohexyl)-N-methyl-acetamide 

Relevant articles and documents

Synthesis, resolution, and absolute configuration of trans-1-amino-2-dimethylaminocyclohexane

Racemic trans-1-amino-2-dimethylaminocyclohexane was prepared by aziridine ring opening reaction of 7-azabicyclo[4.1.0]heptane with HNMe2. The resolution of the racemate was accomplished by crystallization as the L-tartrate. The optical purity

Analgesic N-[2-(furyl-methylamino and 2-thienylmethylamino)cycloaliphatic]be

Cis - and trans-N-(2-aminocycycloaliphatic)benzamide compounds of the formula STR1 e.g., N-methyl-N-[2-[(2-furylmethyl)methylamino]-cyclohexyl]-3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm-blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.