67198-21-4

Usage

Uses

Used in Pharmaceutical Industry:
1,2-Cyclohexanediamine, N,N-dimethyl-, transis used as a chiral amine catalyst for enhancing the selectivity and efficiency of asymmetric direct aldol and Michael addition reactions. This application is crucial in the synthesis of enantiomerically pure compounds, which are essential in the development of many pharmaceutical drugs. The use of this catalyst allows for the production of these compounds with higher yields and better enantioselectivity, ultimately leading to more effective and safer medications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 1,2-Cyclohexanediamine, N,N-dimethyl-, transis used as a chiral amine catalyst to facilitate asymmetric reactions. This is particularly important in the synthesis of complex organic molecules, such as natural products and biologically active compounds. The use of this catalyst can improve the overall yield and selectivity of these reactions, making it a valuable tool for chemists working in various research and development settings.
Used in Research and Development:
1,2-Cyclohexanediamine, N,N-dimethyl-, transis also utilized in research and development laboratories for the study of asymmetric catalysis and the development of new synthetic methods. Its unique properties make it an attractive candidate for exploring novel reaction mechanisms and designing innovative catalysts for various chemical transformations. This can lead to the discovery of new synthetic routes and the development of more efficient and environmentally friendly processes in the chemical industry.

Upstream product

• 152375-95-6 2-dimethylamino-cyclohexanone oxime 
• 286-18-0 7-azabicyclo[4.1.0]heptane 
• 124-40-3 dimethyl amine 
• 71172-32-2 trans-1,2-dinitrocyclohexane 
• 286-20-4 cyclohexane-1,2-epoxide 
• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 30727-29-8 2-dimethylamino-1-cyclohexanol 
• 21651-78-5 trans-2-(N,N-dimethylamino)cyclohexanol 
• 4580-81-8 (+/-)-(trans-2-chloro-cyclohexyl)-dimethyl-amine 

Downstream Products

• 320778-92-5 (1R,2R)-N,N-dimethylcyclohexane-1,2-diamine 
• 67579-25-3 N-((1S,2S)-2-Dimethylamino-cyclohexyl)-4-methoxy-benzamide 
• 67579-13-9 3,4-Dichloro-N-((1S,2S)-2-dimethylamino-cyclohexyl)-benzamide 
• 67198-27-0 trans-N-<2-(dimethylamino)cyclohexyl>formamide 

Relevant academic research and scientific papers

Synthesis, resolution, and absolute configuration of trans-1-amino-2-dimethylaminocyclohexane

Racemic trans-1-amino-2-dimethylaminocyclohexane was prepared by aziridine ring opening reaction of 7-azabicyclo[4.1.0]heptane with HNMe2. The resolution of the racemate was accomplished by crystallization as the L-tartrate. The optical purity

Analgesic N-{2-[N'-(2-furylmethyl and 2-thienyl-methyl)-N'-alkylamino]cycloaliphatic}cyanobenzamides

Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula STR1 e.g., N-methyl-N-[2-(N-pyrrolidinyl)cyclohexyl]-3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.

Analgesic N-[2-(furyl-methylamino and 2-thienylmethylamino)cycloaliphatic]be

Cis - and trans-N-(2-aminocycycloaliphatic)benzamide compounds of the formula STR1 e.g., N-methyl-N-[2-[(2-furylmethyl)methylamino]-cyclohexyl]-3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm-blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.

Analgesic N-(2-aminocycloaliphatic)benzamides

Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula STR1 E.G., N-methyl-N[2-(N-pyrrolidinyl)cyclohexyl[3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.