672-76-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-5-isopropyl-2,4,6-cycloheptatriene-1-one is used as an anti-inflammatory and antimicrobial agent for its potential therapeutic effects in treating various conditions. Its natural presence in plants and ability to combat pathogens make it a promising candidate for pharmaceutical applications.
Used in Chemical Industry:
In the chemical industry, 2-Hydroxy-5-isopropyl-2,4,6-cycloheptatriene-1-one is used as a chelating agent in metal complexation. Its ability to bind with metal ions can be utilized in various chemical processes and the development of new materials.
Used in Food and Cosmetics Industry:
2-Hydroxy-5-isopropyl-2,4,6-cycloheptatriene-1-one is used as an antioxidant in food and cosmetics to extend the shelf life of products and maintain their quality. Its antioxidant properties help protect against the negative effects of oxidation, ensuring freshness and stability.
Used in Organic Synthesis:
2-Hydroxy-5-isopropyl-2,4,6-cycloheptatriene-1-one is used as a building block in the synthesis of organic compounds. Its unique structure and reactivity make it a valuable component in the creation of new and innovative organic molecules for various applications.

InChI:InChI=1/C10H12O2/c1-7(2)8-3-5-9(11)10(12)6-4-8/h3-7H,1-2H3,(H,11,12)

Upstream product

• 22057-93-8 γ-dolabrin 
• 542-92-7 cyclopenta-1,3-diene 
• 57649-49-7 5-isopropylcyclopentadiene 
• 3172-00-7 5-bromotropolone 
• 103204-15-5 2-Amino-5-isopropenyl-tropon 
• 109248-34-2 4-Isopropenyl-2-p-toluolsulfonyloxy-tropon 
• 310905-90-9 [(R)-4-(2,2-Dimethoxy-ethyl)-5-methyl-1-methylene-hexyloxy]-trimethyl-silane 
• 310905-96-5 (5S)-5-isopropyl-1-trimethylsilyloxymethyl-1,3-cycloheptene 
• 310905-91-0 (5R)-5-isopropyl-3-methoxycycloheptanone 
• 310905-97-6 (5S)-2-hydroxy-5-isopropyl-3-cyclohepten-1-one 
• 105897-85-6 (R)-3-(1-methylethyl)-6-oxoheptanal dimethylacetal 
• 310905-98-7 (5S)-5-isopropyl-3-cycloheptene-1,2-dione 
• 66967-10-0 2-chloro-5-isopropyltropone 
• 66967-15-5 2-chloro-6-isopropyl-cycloheptatrienone 

Downstream Products

• 92397-10-9 α,α-bis(7-hydroxy-4-isopropyltropon-2-yl)-4-methoxytoluene 
• 536-66-3 p-isopropylbenzoic acid 
• 29346-20-1 β-thujaplicinol 
• 79-31-2 isobutyric Acid 
• 47785-22-8 La(C₁₀H₁₁O₂)3 
• 53527-02-9 4-isopropyl-2-(2-phenylhydrazino)tropone 
• 69141-45-3 5-isopropyl-2-tosyloxytropone 

Relevant academic research and scientific papers

TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS

Disclosed are a series of compounds or their tautomers having a general structure represented by Formula la or lb and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising said compounds or tautomers or pharmaceutically acceptable salts thereof. Further disclosure relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis, comprising administering to a subject in need thereof a therapeutically effective amount of Formula la or lb compounds or tautomers or pharmaceutically acceptable salts thereof.

Method for preparing gamma-thujaplicin by applying simulated moving bed chromatography

The invention relates to a method for preparing gamma-thujaplicin by applying simulated moving bed chromatography. The method comprises the following steps: generating potassium cyclopentadiene by using cyclopentadiene and potassium hydroxide, carrying out a reaction between potassium cyclopentadiene and isopropyl bromide and heating under the condition of strong alkali and weak acid salt to prepare 2-isopropylcyclopentadiene; performing addition a reaction product of dichloracetyl chloride and triethylamine as well as 2-isopropylcyclopentadiene to prepare 2-isopropylcyclopentadiene ethenone addition product, and performing ring expansion reaction to synthesize a crude product of gamma-thujaplicin; applying a simulated moving bed chromatographic system to separate a crude product of the gamma-thujaplicin and applying a simulated moving bed to purify the gamma-thujaplicin, wherein the total yield of the gamma-thujaplicin is more than 60.0 percent and the purity is more than 97.0 percent. The method has the advantages of simple process, simple and convenient reaction condition, low cost, high yield and capability of meeting the environmental protection requirement.

Regioselective synthesis of β- and γ-thujaplicins

β-Thujaplicin (hinokitiol) 1 and γ-thujaplicin 2, as the first naturally occurring monocyclic tropolone, were regioselectively synthesized from (R)-(+)-limonene, by using different dienyl silyl ether intermediates, 7 and 10, in 18% overall yield via 11 steps and 22% overall yield via 10 steps, respectively. (C) 2000 Elsevier Science Ltd.