67200-57-1Relevant academic research and scientific papers
Chelating Phosphine-N-Heterocyclic Carbene Platinum Complexes via Catalytic Asymmetric Hydrophosphination and Their Cytotoxicity Toward MKN74 and MCF7 Cancer Cell Lines
Seah, Jeffery Wee Kiong,Lee, Jeannie Xue Ting,Li, Yongxin,Pullarkat, Sumod A.,Tan, Nguan Soon,Leung, Pak-Hing
supporting information, p. 17276 - 17287 (2021/11/17)
A series of activated vinyl azoles was hydrophosphinated in the presence of a chiral palladacycle catalyst under mild conditions to give enantioenriched phosphine azoles with moderate enantioselectivities and yields. The racemic phosphine azoles were transformed into eleven novel chelating phosphine-N-heterocyclic carbene (NHC) platinum complexes. The drug efficacies of nine selected phosphine-NHC platinum(II) chlorides in two cancer cell lines (MKN74 and MCF7) were evaluated, and two were found to exhibit activities comparable to that of cisplatin.
