67205-53-2

Basic information

• Product Name: 2,3,5,6-tetrachloro-4-cyanophenyl propanoate
• Synonyms: 2,3,5,6-Tetrachloro-4-cyanophenyl propionate; benzonitrile, 2,3,5,6-tetrachloro-4-(1-oxopropoxy)-
• CAS NO: 67205-53-2
• Molecular Formula: C₁₀H₅Cl₄NO₂
• Molecular Weight: 312.9642
• Mol File: 67205-53-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 406.3°C at 760 mmHg
• Flash Point: 199.5°C
• Density: 1.59g/cm³
• Vapor Pressure: 8.23E-07mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 2,3,5,6-tetrachloro-4-cyanophenyl propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5,6-tetrachloro-4-cyanophenyl propanoate(67205-53-2)
• EPA Substance Registry System: 2,3,5,6-tetrachloro-4-cyanophenyl propanoate(67205-53-2)

Safety Data

• Hazardous Substances Data: 67205-53-2(Hazardous Substances Data)

Usage

General Description

2,3,5,6-tetrachloro-4-cyanophenyl propanoate is a synthetic chemical compound that consists of a propanoate group attached to a 2,3,5,6-tetrachloro-4-cyanophenyl ring. It is commonly used as an intermediate in the production of various other chemicals, particularly those related to pharmaceuticals and agrochemicals. 2,3,5,6-tetrachloro-4-cyanophenyl propanoate is highly toxic and poses serious health and environmental risks, including skin and eye irritation, as well as potential damage to aquatic life. It is important to handle and dispose of 2,3,5,6-tetrachloro-4-cyanophenyl propanoate with caution to minimize its impact on human health and the environment.

Upstream product

• 20925-85-3 pentachlorobenzonitrile 
• 3336-23-0 4-hydroxytetrachlorobenzonitrile 
• 79-03-8 propionyl chloride 

Relevant articles and documents

Synthesis and antiinflammatory evaluation of substituted isophthalonitriles, trimesonitriles, benzonitriles, and terephthalonitriles

In an effort to develop nonacidic, nonsteroidal, antiinflammatory agents without gastrointestinal complications, a series of cyanobenzenes was synthesized for antiinflammatory evaluation. Twenty-seven substituted isophthalonitriles, 19 trimesonitriles, 30 benzonitriles, and 16 terephthalonitriles were tested in the rat utilizing the carrageenan-induced pedal edema assay. Based on the performance of phenylbutazone in this assay (43.8% reduction at 100 mg/kg), six compounds, dosed at 50 mg/kg, produced reductions in inflammation comparable to this standard. However, the LD50 value of each compound dosed at this level was in the range of 40-56 mg/kg in the mouse; therefore, further study was not warranted. Fifteen compounds possessed activity in excess of 20% reduction at 200 mg/kg and also possessed LD50 values greater than 300 mg/kg. Of these cyanobenzenes, trimesonitrile, 4-chlorobenzonitrile, 2-chloroterephthalonitrile, and 2-fluoroterephthalonitrile with reductions in edema of 32, 30, 46, and 49%, respectively, represent the best candidates for subsequent study.