6721-80-8Relevant academic research and scientific papers
2-Allylaminothiazole and 2-allylaminodihydrothiazole derivatives: Synthesis, characterization, and evaluation of bioactivity
Studzińska, Renata,Karczmarska-Wódzka, Aleksandra,Kozakiewicz, Anna,Ko?odziejska, Renata,Paprocka, Renata,Wróblewski, Marcin,Augustyńska, Beata,Modzelewska-Banachiewicz, Bozena
, p. 1673 - 1679 (2015)
Some reactions of selected chlorooxoesters and haloesters with a 1-allylthiourea under various conditions have been performed. The reactions have been performed in methanol in alkaline and neutral environment. Condensation of 1-allylthiourea with chlorooxoesters has been further led via acetal as intermediate compound. As a result, the compounds containing thiazole and a 4,5-dihydrothiazole ring with a good yield have been obtained. The structures of the compounds were verified by 1H NMR, 13C NMR as well as X-ray diffraction analysis. Due to the potential biological activity of the synthesized compounds, the parameters of their bioavailability have been determined, and the probability of pharmacological action has been defined. All of the obtained compounds fulfilled the rule of five, which indicate their good absorption after oral intake. The probability of pharmacological action and potential targets calculated for the obtained compounds show that they can be potential drugs. Graphical abstract: (Equation Presented).
One-Pot Telescoped Synthesis of Thiazole Derivatives from β-Keto Esters and Thioureas Promoted by Tribromoisocyanuric Acid
De Andrade, Vitor S. C.,De Mattos, Marcio C. S.
, p. 4867 - 4874 (2018/12/13)
A simple and efficient one-pot protocol has been developed for the synthesis of thiazole derivatives from readily available starting materials. Tribromoisocyanuric acid was successfully used for α-monohalogenation of β-keto esters in aqueous medium, which
