109-57-9Relevant articles and documents
Unexpected complexation of allylpseudothiohydantoin hydrochlorides towards CuX (X?=?Cl, NO3, ClO4, BF4, 1/2SiF6). The first known examples of joint CuI(Cl,ClO4) and CuI(Cl,BF4) π-complexes
Fedorchuk,Kinzhybalo,Slyvka, Yu. I.,Goreshnik,Bednarchuk,Lis,Mys’kiv
, p. 871 - 884 (2017)
By means of alternating current-electrochemical synthesis starting from a mixture of 2-imino-3-(prop-2-en-1-yl)-1,3-thiazolidin-4-one (3-allylpseudothiohydantoin, napt) and 2-allylamino-1,3-thiazol-4(5H)-one (allylaminopseudothiohydantoin, aapt) hydrochlorides and corresponding copper(II) salts five new π-complexes, [Cu(napt)Cl] (1), [Cu2(aapt)2Cl]NO3 (2), [Cu2(aapt)2Cl]BF4 (3), [Cu2(aapt)2Cl]ClO4 (4) and [Cu2(aapt)2Cl]2SiF6·2H2O (5), were obtained and studied by X-ray single crystal diffraction and IR-spectroscopy. Napt and aapt molecules are selectively coordinated to Cu+ depending on the anion type. In crystals of 1 and 5, the organic ligands are attached to the metal in a chelating N,(C=C)-bidentate mode. The aapt molecule in 2-4 acts as a tridentate chelating ligand, being coordinated to the copper(I) ion through the heterocyclic N atom, carbonyl O atom, and C=C?bond of allyl group, forming an original cationic [Cu2(aapt)2Cl]+ fragment with both a bridging Cl– ion and O atom of the C=O group. In the presence of the doubly charged SiF6 2– anion, Cu(I) in 5 prefers to be bonded with two bridging Cl– ions, rather than the C=O group, causing [Cu2(aapt)2Cl]+ units to associate into the infinite cationic chains. Crystals of 3 and 4 are the first known examples of the simultaneous BF4 –/Cl– or ClO4 –/Cl– participation in copper(I) π-complex formation.
ANTIVIRAL COMPOUNDS AND USE THEREOF
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Page/Page column 36; 39-40, (2019/10/04)
The present invention relates to compounds of formula (I), their use as medicaments, in particular as broad spectrum antiviral agents, their combination with a further antiviral agent and relative pharmaceutical compositions. In particular, the compounds of the invention are useful in the treatment of a disease caused by an enveloped virus.
A pharmaceutical intermediate propenyl thiourea synthesis method (by machine translation)
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Paragraph 0011; 0013; 0014; 0015, (2018/07/30)
A pharmaceutical intermediate propenyl thiourea synthesis method, comprises the following steps: in the reaction container by adding 5 L sodium chloride solution, 4 μM of 3 - methyl isobutyl ketone sulfur cyanic acid benzene, raising the temperature of the solution to 60 - - 65 °C, adding 5 — 6 μM of acrylamide and 6 L acetone solution, reflux 90 - 120 min, layered, take out the oil layer, potassium bromide solution for washing 5 — 7 times, be propylene isothiocyanate, desiccant dehydration, filtering, the filtrate is distilled under reduced pressure, collecting 80 — 86 °C fraction, obtained propylene thiocyanate; the resulting thiocyanate of propylene added to the 5 — 6 μM benzene acetamide, adding 2 L aqueous solution, raising the temperature of the solution to 50 — 60 °C, reaction 50 — 70 min, reduce the temperature of the solution to 10 — 15 °C, separating out crystal, filtering, washing toluene solution, butanone solution washing, dehydrating agent dehydration, to get finished propenyl thiourea. (by machine translation)
