67221-50-5

Usage

Uses

Used in Pharmaceutical Research and Development:
1H-Pyrazole-3-carboxamide,4-amino-(9CI) is used as a key intermediate in the synthesis of various drugs for its versatile chemical properties and potential therapeutic applications.
Used in Antibacterial Applications:
In the field of microbiology, 1H-Pyrazole-3-carboxamide,4-amino-(9CI) is used as an antibacterial agent for its potential to combat bacterial infections, contributing to the development of new antibiotics.
Used in Anti-inflammatory Applications:
1H-Pyrazole-3-carboxamide,4-amino-(9CI) is utilized as an anti-inflammatory agent, leveraging its potential to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Used in Antitumor Applications:
In oncology, 1H-Pyrazole-3-carboxamide,4-amino-(9CI) is explored as an antitumor agent, with studies investigating its capacity to inhibit tumor growth and its potential synergistic effects with existing cancer therapies.
Used in Drug Synthesis:
1H-Pyrazole-3-carboxamide,4-amino-(9CI) is employed as a building block in the creation of new pharmaceutical compounds, owing to its reactive amide and amino groups that facilitate chemical modifications and improvements in drug design.

InChI:InChI=1/C4H6N4O/c5-2-1-7-8-3(2)4(6)9/h1H,5H2,(H2,6,9)(H,7,8)

Upstream product

• 65190-36-5 4-nitro-1H-pyrazole-5-carboxamide 

Downstream Products

• 13877-55-9 pyrazolo<4,3-d>pyrimidin-7-one 
• 40769-81-1 pyrazolo<4,3-d>pyrimidine-5,7-(1H,4H,6H)-dione 
• 1403819-33-9 5-phenyl-1,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one 
• 80186-70-5 4-((N-benzoylthiocarbamoyl)amino)pyrazole-3-carboxamide 

Relevant academic research and scientific papers

HETEROCYCLIC GTP CYCLOHYDROLASE 1 INHIBITORS FOR THE TREATMENT OF PAIN

The present invention relates to the field of small molecule heterocyclic inhibitors of GTP cyclohydrolase (GCH-I), or a tautomer, prodrug, or pharmaceutically acceptable salt thereof. The invention also features pharmaceutical compositions of the compounds and the medical use of these compounds for the treatment or prevention of pain (e.g., inflammatory pain, nociceptive pain, functional pain, or neuropathic pain).

Pyrazole-Related Nucleosides. Synthesis and Antiviral/Antitumor Activity of Some Substituted Pyrazole and Pyrazolo-1,2,3-triazin-4-one Nucleosides

Several pyrazole and pyrazolo-1,2,3-triazin-4-one ribonucleosides were prepared and tested for antiviral/antitumor activities.Appropriate heterocyclic bases were prepared by standard methodologies.Glycosylation of pyrazoles 6a-e,g,i and pyrazolo-1,2,3-triazin-4-ones 12f-l mediated bu silylation with hexamethylsilazane, with 1-β-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose gave in good yields the corresponding glycosides 7a-e,g, 8g,i 13f,h,k, and 14f, but could not be applied to compounds 12g,i,j,l.To overcome this occurrence, a different strategy involvi ng the preparation, diazotization, and in situ cyclization of opportune pyrazole glycosides 9 and 10 was reguired.Moreover derivatives having the general formula 5 were considered not only as synthetic intermediates in the synthesis of 3 but also as carbon bioisosteres of ribavirin 4.All compounds were evaluated in vitro for cytostatic and antiviral activity.The pyrazolo-1,2,3-triazin-4-one nucleosides that resulted were substantially devoid of any activity; only 15h,k showed a moderate cytostatic activity against T-cells.However, pyrazole nucleosides 9b,c,e were potent and selective cytotoxic agents against T-lymphocytes, whereas 9e showed a selective, although not very potent, activity against coxsackie B1.