65190-36-5

Basic information

• Product Name: 4-NITRO-2H-PYRAZOLE-3-CARBOXAMIDE
• Synonyms: 4-NITRO-2H-PYRAZOLE-3-CARBOXAMIDE;Pyrazole-3-carboxamide, 4-nitro-
• CAS NO: 65190-36-5
• Molecular Formula: C₄H₄N₄O₃
• Molecular Weight: 156.1
• Mol File: 65190-36-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 460.532 °C at 760 mmHg
• Flash Point: 232.321 °C
• Appearance: /
• Density: 1.706 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-NITRO-2H-PYRAZOLE-3-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITRO-2H-PYRAZOLE-3-CARBOXAMIDE(65190-36-5)
• EPA Substance Registry System: 4-NITRO-2H-PYRAZOLE-3-CARBOXAMIDE(65190-36-5)

Safety Data

• Hazardous Substances Data: 65190-36-5(Hazardous Substances Data)

Usage

General Description

4-NITRO-2H-PYRAZOLE-3-CARBOXAMIDE is a chemical compound with the molecular formula C4H3N5O3. It is a derivative of pyrazole, a five-membered heterocyclic compound containing nitrogen atoms. The presence of a nitro group in the 4-position and a carboxamide group in the 3-position makes this compound a nitrocarboxamide. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals due to its reactivity and versatility. Additionally, its nitro and carboxamide functional groups make it a useful intermediate for the production of various compounds with medicinal and biological activities.

Upstream product

• 138786-86-4 methyl 4-nitro-1H-pyrazole-3-carboxylate 
• 5334-40-7 4-nitro-1H-pyrazole-3-carboxylic acid 
• 518990-55-1 4-nitro-1H-pyrazole-3-carboxylic acid 
• 55864-87-4 4-nitro-1H-pyrazole-3-carboxylic acid ethyl ester 
• 518990-55-1 4-nitro-1H-pyrazole-5-carbonyl chloride 

Downstream Products

• 67221-50-5 4-aminopyrazole-3-carboxamide 
• 61241-07-4 4-Nitro-1H-5-pyrazolecarbonitrile 
• 786681-98-9 1-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-4-nitro-1H-pyrazole-3-carboxamide 
• 61241-07-4 4-nitro-1H-pyrazole-3-carbonitrile 
• 16115-82-5 4-nitro-1H-pyrazol-3-amine 
• 67221-50-5 4-amino-1H-pyrazole-5-carboxamide 

Relevant articles and documents

Design, synthesis, and cytotoxic activity of novel 2H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidine derivatives

In this study, a series of novel 2H-imidazo [1, 2-c] pyrazolo [3, 4-e] pyrimidine derivatives were designed, synthesized, and evaluated for their cytotoxic activities. The in vitro cell growth inhibition assay of the target compounds indicated their selectivity in inhibiting the proliferation of blood tumor cells (K562, U937) and solid tumor cells (HCT116, HT-29). Compound 9b exhibited the highest antiproliferative activities against K562 (IC50 = 5.597 μM) and U937 (IC50 = 3.512 μM). Based on the flow cytometry assays, compound 9b caused obvious induction of cell apoptosis and cell arrest at the S phase. Furthermore, western blot analysis revealed that compound 9b upregulated the expression of Bax, downregulated the levels of Bcl-2, and further activated caspase-3 in K562 cells. Therefore, compound 9b may be a potential anticancer agent that deserves further investigation.

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