67227-92-3

Upstream product

• 762-04-9 phosphonic acid diethyl ester 
• 103-26-4 methyl cinnamate 
• 1067-74-9 Methyl diethylphosphonoacetate 
• 100-52-7 benzaldehyde 
• 103-26-4 Methyl cinnamate 

Downstream Products

• 67488-47-5 2-phenyl-2,5-dihydro-thiophene-3-carboxylic acid methyl ester 
• 112178-00-4 1,1-Dioxo-2-phenyl-2,4,5,6,7,7a-hexahydro-1H-1λ⁶-benzo[b]thiophene-3-carboxylic acid methyl ester 
• 112178-01-5 4,5-Dimethyl-1,1-dioxo-2-phenyl-2,5-dihydro-1H-1λ⁶-thiophene-3-carboxylic acid methyl ester 
• 112178-05-9 (Z)-2-Cyclohex-1-enyl-3-phenyl-acrylic acid methyl ester 
• 112178-06-0 (E)-3-Methyl-2-[1-phenyl-meth-(Z)-ylidene]-pent-3-enoic acid methyl ester 
• 67488-51-1 1,1-dioxo-2-phenyl-2,5-dihydro-1λ⁶-thiophene-3-carboxylic acid methyl ester 
• 112177-96-5 2-Phenyl-2,4,5,6,7,7a-hexahydro-benzo[b]thiophene-3-carboxylic acid methyl ester 
• 112177-97-6 4,5-Dimethyl-2-phenyl-2,5-dihydro-thiophene-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Method for preparing (E)-2-aryl-alpha, beta-unsaturated carbonyl phosphonate derivative

The invention discloses a method for preparing a (E)-2-aryl-alpha, beta-unsaturated carbonyl phosphonate derivative (I) (please the formula in the description), and belongs to the field of organic chemistry. According to the method, a 2-aryl-alpha, beta-unsaturated carbonyl compound and phosphite ester serve as raw materials and react with tetrahydrofuran (THF) and other materials as a solvent under the combined action of AgNO3 catalyzing and an assistant agent at the temperature of 20-80 DEG C, and then the (E)-2-aryl-alpha, beta-unsaturated carbonyl phosphonate derivative is obtained. According to the method, the 2-aryl-alpha, beta-unsaturated carbonyl compound serves as the initial raw material, the raw materials are low in price and easy to obtain, reaction conditions are mild, operation is easy and convenient, the synthesis yield is high, and industrial production is facilitated. The derivative has potential application in chemical engineering, medicine, cosmetics and other fields, and a new approach is provided for synthesis of the (E)-2-aryl-alpha, beta-unsaturated carbonyl phosphonate derivative.

Silver-catalyzed direct regioselective phosphonation of β-aryl-α, β-unsaturated carbonyl compounds with H-phosphites under microwave irradiation

An efficient protocol for silver-catalyzed direct radical phosphonation of β-aryl-α,β-unsaturated carbonyl compounds with H-phosphites to afford trans-substituted alkenylphosphonates under microwave irradiation is described. Some notable features of this

A catalytic Michael/Horner-Wadsworth-Emmons cascade reaction for enantioselective synthesis of thiochromenes

A catalytic enantioselective sulfa-Michael/Horner-Wadsworth-Emmons reaction cascade has been developed, taking advantage of phosphonate as an electrophilic activator and a traceless binding site. Using a chiral bifunctional urea derivative as the catalyst, a variety of aryl and heteroaryl substituted thiochromenes was obtained in excellent yield with a high level of enantioselectivity. Copyright