672310-73-5Relevant academic research and scientific papers
Catalytic Oxidative Coupling Cyclization for Construction of Benzofuroindolenines under Mild Reaction Conditions
Lin, Yuqi,Ye, Jinxiang,Zhang, Wenting,Gao, Yu,Chen, Haijun
supporting information, p. 432 - 435 (2018/12/13)
We describe iron-catalyzed oxidative coupling cyclization of tetrahydrocarbazoles or THβCs or THγCs to form benzofuroindolenines as fused polycyclic indoles. This mild, efficient and simple approach afforded a library of more than 52 complex compounds across a range of substrate classes with good to excellent yields. (Figure presented.).
Efficient and straightforward synthesis of tetrahydrocarbazoles and 2,3-dimethyl indoles catalyzed by CAN
Varma, P. Prabhakara,Sherigara, Bailure S.,Mahadevan, Kittapa M.,Hulikal, Vijaykumar
experimental part, p. 158 - 165 (2009/04/07)
A simple protocol was established to synthesize 2,3-dialkyl indoles and various tetrahydrocarbazoles via Fischer indole synthesis. This method uses ceric ammonium nitrate as a catalyst for the Fischer indole synthesis with substituted phenyl hydrazine hydrochlorides and 2-butanone, phenyl propanal, and cyclohexanone. This process is a practical synthetic method for the preparation of various 2,3-disubstituted alkyl indoles and tetrahydrocarbazoles. Copyright Taylor & Francis Group, LLC.
Antimony (III) sulfate catalyzed one-pot synthesis of 2,3- disubstitutedindoles
Srinivasa,Mahadevan,Varma, P. Prabhakara,Sudhakara
experimental part, p. 1843 - 1853 (2010/02/28)
A novel one-pot Fischer indole synthesis approach has been developed by using antimony (III) sulfate as the catalyst. Good yields were obtained after reacting phenylhydrazines hydrochlorides and ketones in refluxing methanol. The exclusive formation of 2,3- disubstituted indoles was observed in the reaction of ethyl methyl ketone with phenylhydrazines. One-pot synthesis of indole-3-propanol using dihydropyran has also been described. The use of reusable antimony (III) sulfate as a catalyst makes this method both economically and environmentally friendly.
Bismuth nitrate promoted fischer indole synthesis: A simple and convenient approach for the synthesis of alkyl indoles
Sudhakara, Aralihalli,Jayadevappa, Honnali,Kumar, Hosanagara N.H.,Mahadevan, Kittappa M.
scheme or table, p. 159 - 164 (2010/04/23)
A novel one-pot fisher indole synthesis approach has been developed by using bismuth nitrate as a catalyst. Yields around 90-95% were obtained after reaction in methanol at reflux temperature in 20-40 min. Apart from the mild reaction conditions of the process and its excellent results, the simplicity of product isolation and the possibility to recycle the bismuth nitrate offers a significant advantage.
Fischer indole synthesis in bronsted acidic ionic liquids: A green, mild, and regiospecific reaction system
Xu, Dan-Qian,Yang, Wen-Long,Luo, Shu-Ping,Wang, Bing-Tao,Wu, Jian,Xu, Zhen-Yuan
, p. 1007 - 1012 (2008/03/12)
A novel one-pot Fischer indole synthesis approach has been developed by using Bronsted acidic ionic liquids as dual solvent-catalysts. Yields of 83-97 % were obtained after reaction in BMImHSO4 at 70-110°C in 0.5-6 h, and exclusive formation of 2,3-disubstituted indoles was observed in the reaction of alkyl methyl unsymmetrical ketones. The indoles produced could be conveniently separated from the reaction mixture without any volatile organic solvents, and the BMImHSO4 could be readily reused without efficiency loss after simple treatment involving only 1 equiv. of HCl for neutralization followed by filtration. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
The regiospecific Fischer indole reaction in choline chloride· 2ZnCl2 with product isolation by direct sublimation from the ionic liquid
Morales, Raul Calderon,Tambyrajah, Vasuki,Jenkins, Paul R.,Davies, David L.,Abbott, Andrew P.
, p. 158 - 159 (2007/10/03)
The Fischer indole synthesis occurs in high yield with one equivalent of the ionic liquid choline chloride·2ZnCl2; exclusive formation of 2,3-disubstituted indoles is observed in the reaction of alkyl methyl ketones, and the products readily sublime directly from the ionic liquid.
