67242-91-5Relevant academic research and scientific papers
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents
Saccoccia, Fulvio,Brindisi, Margherita,Gimmelli, Roberto,Relitti, Nicola,Guidi, Alessandra,Saraswati, A Prasanth,Cavella, Caterina,Brogi, Simone,Chemi, Giulia,Butini, Stefania,Papoff, Giuliana,Senger, Johanna,Herp, Daniel,Jung, Manfred,Campiani, Giuseppe,Gemma, Sandra,Ruberti, Giovina
, p. 100 - 113 (2020)
Schistosomiasis (also known as bilharzia) is a neglected tropical disease caused by platyhelminths of the genus Schistosoma. The disease is endemic in tropical and subtropical areas of the world where water is infested by the intermediate parasite host, t
Preparation method of substituted thiophene-3-one compound
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Paragraph 0100; 0102; 0103, (2018/08/04)
The invention provides a preparation method of a substituted thiophene-3-one compound, comprising: subjecting material A and material B to Michael addition reaction to obtain an addition product; subjecting the addition product to Dieckmann condensation reaction to obtain a substituted thiophene-3-one compound having a structure shown as formula (IV) that is shown in the description. The preparation method provided by the application has the advantages that using solvents and strong bases is not required, reaction materials are low in price and easy to obtain, no wastewater is produce, and therefore, the preparation method has good environmental friendliness; compared with existing preparation methods, the preparation method has a short synthetic route, can be performed under mild conditions and features good yield stability and good repeatability, which is helpful for greatly increasing total yield of the substituted thiophene-3-one compound and helpful for industrial popularization.
A microwave-assisted facile regioselective Fischer indole synthesis and antitubercular evaluation of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles
Karthikeyan, Subramanian Vedhanarayanan,Perumal, Subbu,Shetty, Krithika Arun,Yogeeswari, Perumal,Sriram, Dharmarajan
supporting information; experimental part, p. 3006 - 3009 (2010/03/03)
A series of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles has been synthesised regioselectively in good yields from the reaction of 5-aryldihydro-3(2H)-thiophenones and arylhydrazine hydrochloride. This reaction is found to be assisted by microwaves. T
