36748-19-3

Upstream product

• 106167-58-2 3-oxo-5-phenyl-tetrahydro-thiophene-2-carboxylic acid methyl ester 
• 80278-80-4 3-oxo-5-phenyltetrahydrothiophen-2-ethylcarboxylate 
• 38293-64-0 ethyl 2-phenyl-4-oxothiolane-3-carboxylate 
• 4192-77-2 ethyl cinnamate 
• 82617-90-1 2-chloroacetyl-3-phenyl-acrylic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 67242-91-5 3-[(carboxymethyl)thio]-3-phenylpropanoic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 68-11-1 mercaptoacetic acid 

Downstream Products

• 17517-73-6 2,9-diphenyl-2,3-dihydrothieno[3,2-b]quinoline 
• 17592-92-6 9-methyl-2-phenyl-2,3-dihydro-thieno[3,2-b]quinoline 
• 2832-97-5 4-(4-morpholyl)-2-phenylthiophene 
• 75782-80-8 4,5-dihydro-5-phenyl-3(2H)-thiophenone oxime 
• 177540-95-3 (5-phenylthiophen-3-yl)acetonitrile 
• 83495-21-0 5,5'-diphenyl-2,3'-bithienyl 
• 75782-59-1 2-phenyl-4-(1-pyrrolidinyl-2,2,5,5-d⁴)thiophene 
• 75782-61-5 methyl 6,7,7a,8-tetrahydro-8-(methoxycarbonyl)-2-phenyl-5H-thieno<2,3-b>pyrrolizine-5,5,7a-d₃-8-acetate-d 

Relevant academic research and scientific papers

Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents

Schistosomiasis (also known as bilharzia) is a neglected tropical disease caused by platyhelminths of the genus Schistosoma. The disease is endemic in tropical and subtropical areas of the world where water is infested by the intermediate parasite host, t

A microwave-assisted facile regioselective Fischer indole synthesis and antitubercular evaluation of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles

A series of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles has been synthesised regioselectively in good yields from the reaction of 5-aryldihydro-3(2H)-thiophenones and arylhydrazine hydrochloride. This reaction is found to be assisted by microwaves. T

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.