67247-13-6

Basic information

• Product Name: 7-METHOXY-1-NAPHTHOL
• Synonyms: 7-METHOXY-1-NAPHTHOL;7-Methoxy-1-naphthalenol;1-Hydroxy-7-Methoxynaphthalene;7-Methoxynaphthalen-1-ol;AgoMelatine IMpurity D;7-Methoxy-1-naphthalenol, >=95%;Agomelatine Impurity 12
• CAS NO: 67247-13-6
• Molecular Formula: C₁₁H₁₀O₂
• Molecular Weight: 174.2
• Product Categories: Aromatics;Intermediates
• Mol File: 67247-13-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 122-124℃
• Boiling Point: 336.7±15.0 °C(Predicted)
• Appearance: /
• Density: 1.193±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 9.50±0.40(Predicted)
• CAS DataBase Reference: 7-METHOXY-1-NAPHTHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-1-NAPHTHOL(67247-13-6)
• EPA Substance Registry System: 7-METHOXY-1-NAPHTHOL(67247-13-6)

Safety Data

• Hazardous Substances Data: 67247-13-6(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Different sources of media describe the Uses of 67247-13-6 differently. You can refer to the following data:
1. 7-Methoxy-1-naphthalenol
2. 7-Methoxy-1-naphthalenol is used in the synthesis of Agomelatine (A430000).

Upstream product

• 91142-97-1 4-(p-methoxyphenyl)-3-butenoic acid 
• 19061-33-7 6-methoxy-1,4-dihydro-1,4-epoxidonaphthalene 
• 110-00-9 furan 
• 135678-30-7 2-bromo-4-methoxyphenyl toluene-p-sulphonate 
• 93-04-9 2-Methoxynaphthalene 
• 4900-68-9 2-Methoxy-8-nitronaphthalene 
• 607-39-6 8-nitro-2-naphthol 
• 17332-11-5 2-bromo-4-methoxyphenol 
• 6836-19-7 7-Methoxy-1-tetralone 
• 575-38-2 1,7-Dihydroxynaphthalene 
• 74-88-4 methyl iodide 
• 85928-57-0 2-bromo-7-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 

Downstream Products

• 53568-05-1 8-hydroxy-2-tetralone 
• 35153-30-1 3,5-Diiod-L-tyrosin-7'-hydroxy-1'-naphthylaether 
• 35153-04-9 N-Acetyl-3,5-diiod-L-tyrosinaethylester-7'-methoxy-1'-naphthylaether 
• 1430209-68-9 7-methoxy-1-(1-phenylvinyl)naphthalen-2-ol 
• 1430210-19-7 C₂₆H₂₀O₂ 
• 1430209-81-6 7-methoxy-1-(1-(4-methoxyphenyl)vinyl)naphthalen-2-ol 
• 1430209-76-9 7-methoxy-1-(1-p-tolylvinyl)naphthalen-2-ol 
• 1430210-20-0 C₂₇H₂₂O₂ 

Relevant articles and documents

Enzymatic resolution of 5-hydroxy- and 8-hydroxy-2-tetralols using immobilized lipases

(R)-2-Tetralol (R)-2a, (R)-5-hydroxy-2-tetralol (R)-2b and (R)-8-hydroxy-2-tetralol (R)-2c, which are key intermediates in the synthesis of pharmacologically active 2-aminotetralins 3, were prepared in moderate to very high enantiomeric excess (up to 99% ee) by enzymatic resolution of the corresponding racemic butyrates rac-1a, rac-1b and rac-1c, respectively, using lipases immobilized on octyl agarose. This methodology is an alternative to the microbial reduction of 2-tetralones.

Synthesis of a C8 oxygenated pyranonaphthoquinone: a useful precursor to dimeric pyranonaphthoquinones

The synthesis of a pyranonaphthoquinone bearing an oxygenated substituent at C8 is reported. The oxygen substituent at C8 provides a key functionality for use as a homocoupling precursor for the synthesis of a dimeric pyranonaphthoquinone.