67263-06-3

Upstream product

• 67263-05-2 ethyl 3-(dimethyl(phenyl)silyl)-3-phenylpropionate 
• 14371-10-9 (E)-3-phenylpropenal 
• 1145-98-8 1,2-diphenyltetramethyldisilane 
• 3839-31-4 dimethyl(phenyl)silyl lithium 
• 4192-77-2 ethyl cinnamate 
• 103-26-4 Methyl cinnamate 
• 3839-31-4 dimethyl(phenyl)silyllithium 
• 94286-28-9 4-(dimethylphenylsilyl)-3-phenylpropanoic acid methyl ester 

Downstream Products

• 191916-86-6 (Z)-5-(Dimethyl-phenyl-silanyl)-5-phenyl-pent-2-enoic acid methyl ester 
• 191916-84-4 (E)-5-(Dimethyl-phenyl-silanyl)-5-phenyl-pent-2-enoic acid methyl ester 
• 2768-42-5 (R)-3-phenyl-3-hydroxypropionic acid 
• 5381-86-2 (+/-)-(RS,RS)-1,3-diphenyl-1,3-propanediol 
• 5381-86-2 (1R,3S)-1,3-diphenylpropane-1,3-diol 
• 191917-31-4 2-[3-(Dimethyl-phenyl-silanyl)-3-phenyl-propylidene]-malonic acid dimethyl ester 
• 164203-14-9 (3S)-3-dimethyl(phenyl)silyl-3-phenylpropanoic acid 
• 153221-16-0 (R)-3-(dimethylphenylsilyl)-3-(phenyl)propanoic acid 

Relevant academic research and scientific papers

Conjugate additions of a simple monosilylcopper reagent with use of the CuI-DMS complex: Stereoselectivities and a dramatic impact by DMS

(Chemical Equation Presented) Conjugate additions utilizing the simple monosilylcuprate reagent Li[PhMe2SiCuI] to α,β-unsaturated carbonyl compounds are described. The presence of dimethyl sulfide (DMS), either as a component originating from t

Employing the simple monosilylcopper reagent, Li[PhMe2SiCuI], in 1,4-addition reactions

Conjugate addition reactions using the simple Li[PhMe2SiCuI] reagent to a variety of α,β-unsaturated carbonyl compounds is described; dimethyl sulfide from the purification of CuI plays a key role for very high yields as well as high stereosele

A synthesis of enantiomerically enriched propargyl silanes

Reduction of ethyl 3-methyl-, 3-isopropyl- and 3-n-pentyl-3-[dimethyl(phenyl)silyl]propanoates 4 with DIBAL to the aldehydes 5, enol trifluoromethanesulfonate (triflate) formation using trifluoromethanesulfonic (triflic) anhydride and 2,6-di-tert-butylpyridine, and elimination using LDA, gives the propargyl silanes 8. The esters 4 could also be prepared enantiomerically enriched (11), and the final products are the enantiomerically enriched propargyl (homochiral) silanes 14.

In search of open-chain 1,3-stereocontrol

Methylation of methyl 4-phenylpentanoate 25 gives the diastereoisomers methyl (2RS,4SR)-2-methyl-4-phenylpentanoate 26 and methyl (2RS,4RS)- 2-methyl-4-phenylpentanoate 27 in a ratio of 44:56. The aldehydes 3-dimethyl(phenyl)silylbutanal 28, 3-dimethyl(ph

Conjugate Addition of the Phenyldimethylsilyl Group to αβ-Unsaturated Carbonyl Compounds Using a Silylzincate in Place of the Silylcuprate

Lithium phenyldimethylsilyl(dialkyl)zincates add to a number of αβ-unsaturated carbonyl compounds to give, in most cases, higher yields of the conjugate addition product than we had achieved with the corresponding silylcuprate.