67273-44-3Relevant academic research and scientific papers
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles
Tsukamoto,Yoshino,Kohno,Ohtaka,Kagaya,Ito
, p. 734 - 738 (2007/10/02)
A series of 2-(2-pyridinyl)benzimidazoles was synthesized and evaluated for antiinflammatory activity by the carrageenan-induced rat paw edema assay. Among several active derivatives, 2-(5-ethylpyridin-2-yl)benzimidazole was selected for further study. A comparison of this compound with phenylbutazone and tiaramide revealed that it possesses stronger activity in acute inflammatory models possibly with slightly less gastrointestinal irritation than both phenylbutazone and tiaramide.
2-Substituted benzimidazole compounds
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, (2008/06/13)
2-Substituted benzimidazole compounds of the formula: STR1 wherein R 1 is hydrogen, halogen, lower alkyl or lower alkoxy, and R 2 is hydrogen or lower alkyl with the proviso that R 1 and R 2 do not stand for hydrogen simultaneously and, when R 1 is hydrogen, R 2 cannot mean a methyl group at the 6th position on the pyridin-2-yl group or methyl an isobutyl group on the phenyl group; are useful as anti-inflammatory agents and/or analgesics.
