67273-44-3Relevant articles and documents
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles
Tsukamoto,Yoshino,Kohno,Ohtaka,Kagaya,Ito
, p. 734 - 738 (2007/10/02)
A series of 2-(2-pyridinyl)benzimidazoles was synthesized and evaluated for antiinflammatory activity by the carrageenan-induced rat paw edema assay. Among several active derivatives, 2-(5-ethylpyridin-2-yl)benzimidazole was selected for further study. A comparison of this compound with phenylbutazone and tiaramide revealed that it possesses stronger activity in acute inflammatory models possibly with slightly less gastrointestinal irritation than both phenylbutazone and tiaramide.