67273-47-6Relevant academic research and scientific papers
Differential antiproliferative activity of new benzimidazole-4,7-diones
Garuti, Laura,Roberti, Marinella,Pizzirani, Daniela,Pession, Annalisa,Leoncini, Emanuela,Cenci, Valentina,Hrelia, Silvana
, p. 663 - 668 (2007/10/03)
Ten benzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Several compounds showed a significant antiproliferative activity on K562 cells, although to a different extent, whereas compound 1i showed a highly significant activity on SW620 cells, comparable to that of doxorubicin. Both the substituents in the quinone ring and the position of the nitrogen atom in the pyridine moiety play a crucial role for the biological activity.
Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles
Tsukamoto,Yoshino,Kohno,Ohtaka,Kagaya,Ito
, p. 734 - 738 (2007/10/02)
A series of 2-(2-pyridinyl)benzimidazoles was synthesized and evaluated for antiinflammatory activity by the carrageenan-induced rat paw edema assay. Among several active derivatives, 2-(5-ethylpyridin-2-yl)benzimidazole was selected for further study. A comparison of this compound with phenylbutazone and tiaramide revealed that it possesses stronger activity in acute inflammatory models possibly with slightly less gastrointestinal irritation than both phenylbutazone and tiaramide.
