67294-54-6

Upstream product

• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 34461-00-2 nitromalondialdehyde sodium salt 
• 36669-06-4 dimethyl 2-hydroxyisophthalate 

Downstream Products

• 67294-57-9 5-Amino-2-hydroxyisophthalsaeure-dimethylester 
• 634558-46-6 2,6-bis(methylaminocarbonyl)-4-nitrophenol 
• 337520-69-1 dimethyl 2-(1-t-butoxycarbonylpiperidin-4-yloxy)-5-nitroisophthalate 
• 634558-47-7 4-amino-2,6-bis(methylaminocarbonyl)phenol 

Relevant academic research and scientific papers

BENZAMIDINE DERIVATIVES

Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: wherein R 1represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R 2represents a hydrogen atom, a halogen atom or an alkyl group, R 3represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkanoyl group or an optionally substituted alkylsulfonyl group, R 4and R 5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group, and R 6represents a substituted pyrrolidine group or substituted piperidine group.

Syntheses and UV-visible spectroscopic properties of two new hydrophilic 2,6-di(carbamoyl)-substituted solvatochromic pyridinium N-phenolate betaine dyes

Synthesis and negative solvatochromism of two 2,6-di(carbamoyl) -substituted pyridinium N-phenolate betaines dyes were investigated. The exceptionally large negative solvatochromism of the standard betaine dye was used to establish a UV-Vis spectroscopically derived scale of solvent polarity. It was found that the primary indicator dye was sufficiently soluble in most organic solvents.