36669-06-4

Usage

Uses

Used in Organic Synthesis:
DiMethyl 2-Hydroxyisophthalate is used as a reactant for the synthesis of calix[2]phenol[2]pyrrole 4, a complex organic molecule with potential applications in various fields. Its unique structure allows for the formation of this molecule, which may have properties that are beneficial for specific applications.
Used in Chemical Research:
DiMethyl 2-Hydroxyisophthalate can be utilized in chemical research to explore new reactions and develop novel synthetic pathways. Its reactivity and structural features make it an interesting candidate for studying various chemical transformations and understanding the underlying mechanisms.
Used in Material Science:
In the field of material science, DiMethyl 2-Hydroxyisophthalate may be employed as a building block for the development of new materials with specific properties. Its incorporation into larger structures could lead to materials with enhanced performance characteristics, such as improved stability, reactivity, or selectivity.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, DiMethyl 2-Hydroxyisophthalate could potentially be used in the pharmaceutical industry as a starting material for the synthesis of drug candidates. Its unique structure and reactivity may enable the development of new drugs with improved efficacy and selectivity.

Upstream product

• 186581-53-3 diazomethane 
• 606-19-9 2-hydroxyisophthalic acid 
• 67-56-1 methanol 
• 576-22-7 2-Bromo-m-xylene 
• 90772-05-7 2-acetoxy-isophthalic acid 
• 542-78-9 Malondialdehyde 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 927-63-9 (E)-3-(dimethylamino)acrolein 
• 24382-04-5 malonaldehyde sodium salt 
• 24316-94-7 C₆H₁₂NO⁽¹⁺⁾*CH₃O₄S^(1-) 
• 624-67-9 Propargylic aldehyde 
• 83-40-9 3-methylsalicylic acid 
• 36727-13-6 2-methoxy-1,3-benzenedicarboxylic acid dimethyl ester 
• 1951-38-8 2-methoxyisophthalic acid 

Downstream Products

• 111635-74-6 2-methoxy-1,3-benzenedimethanol 
• 847255-77-0 C₂₁H₃₀O₆ 
• 67294-54-6 2-hydroxy-5-nitro-isophthalic acid dimethyl ester 
• 1141722-26-0 dimethyl 2-(3-(tert-butoxycarbonylamino)propoxy)isophthalate 
• 1357909-91-1 2,2'-(2-hydroxy-1,3-phenylene)dipropan-2-ol 
• 1357909-92-2 2-(2-(1H-pyrrol-2-yl)propan-2-yl)-6-(2-hydroxypropan-2-yl)phenol 
• 263160-77-6 dimethyl 5-iodo-2-{[(trifluoromethyl)sulphonyl]oxy}isophthalate 
• 101670-85-3 methyl 3-carboxysalicylate 
• 2937-59-9 2,6-bis(hydroxymethyl)phenol 

Relevant academic research and scientific papers

Tetramethyl 3,7-Dihydroxybicyclonona-2,6-diene-2,4,6,8-tetracarboxylate: A Useful Companion to Meerwein's Ester. Topological Analysis of Bicyclononane Synthesis

The pH dependence of the condensation of dimethyl 3-oxoglutarate and malondialdehyde to produce 2,6-bis(methoxycarbonyl)phenol and tetramethyl 3,7-dihydroxybicyclonona-2,6-diene-2,4,6,8-tetracarboxylate has been studied in detail: the yield of the former is maximal at pH 4,5, the latter at pH 7.5.The hydrolysis-decarboxylation of the latter provides a convenient route to bicyclononane-3,7-dione.The mechanism proposed for this reaction of malonodialdehyde is also relevant to the chemistry of glyoxal and dimethyl 3-oxoglutarate.The retrosynthetic analysis of the bicyclononane skeleton is considered from a topological perspective.

Functionalized hydrazide macrocycle ion channels showing pH-sensitive ion selectivities

Transmembrane channels formed by functionalized hydrazide macrocycles are reported. The different pH values of buffer solutions have a significant effect on the K+/Cl- selectivity of the macrocycles. This unique transport behavior is

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.

Multinuclear non-heme iron complexes for double-strand DNA cleavage

The cytotoxicity of the antitumor drug BLM is believed to be related to the ability of the corresponding iron complex (Fe-BLM) to engage in oxidative double-strand DNA cleavage. The iron complex of the ligand N4Py (Fe-N4Py; N4Py = N,N-bis(2-pyridyl)-N-bis

Labile linkage for compound delivery to a cell

Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different mo

BENZAMIDINE DERIVATIVES

Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: wherein R 1represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R 2represents a hydrogen atom, a halogen atom or an alkyl group, R 3represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkanoyl group or an optionally substituted alkylsulfonyl group, R 4and R 5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group, and R 6represents a substituted pyrrolidine group or substituted piperidine group.

Protected nucleoside and method for its synthesis

The present invention relates to a nucleoside having the formula: STR1 where R1 is a hydrogen or a protecting group; R2 is a hydrogen or a coupling group; R3 and R4 are each either a hydrogen or an alkyl group, where R3 and R4 can be connected in a ring; R5 is a hydrogen, an alkyl group, or a carboxylic ester group; R6 is a hydrogen, an alkyl group, or a carboxylic ester group; R7 is a hydrogen, a nitro group, a halogen, a cyano group, or an alkyl group, where R7 is attached at either position 4, 5 or 6; and Base is a protected heterocyclic base. Further, the present invention relates to a method of making the nucleoside and a method of oligomer synthesis utilizing the nucleoside.

A Convenient One-Pot Method for the Construction of Tetrasubstituted Phenols through a Michael Addition-Aldol Cyclization Sequence

The sodium salt of dimethyl 1,3-acetonedicarboxylate (1) readily reacts with certain alkynals under mild conditions in THF to give a tetrasubstituted aromatic ring with regiocontrol at the metaposition through a Michael addition-aldol cyclization sequence. Thus the reaction of I with propynal, 2-butynal, 2-pentynal, 2-octynal, 4-(benzoyloxy)-2-butynal, and 4-((tetrahydropyranyl)-oxy)-2-butynal at 25 °C gave the following products: dimethyl 2-hydroxybenzene-1,3-dicarboxylate (11percent), dimethyl 2-hydroxy-4-methylbenzene-1,3-dicarboxylate (45percent), dimethyl 4-ethyl-2-hydroxybenzene-1,3-dicarboxylate (46percent), dimethyl 2-hydroxy-4-pentylbenzene-1,3-dicarboxylate (42percent), dimethyl 2-hydroxy-4-((pivaloyloxy)methyl)benzene-1,3-dicarboxylate (88percent), dimethyl 2-hydroxy-4-((benzoyloxy)methyl)benzene-1,3-dicarboxylate (74percent), and dimethyl 2-hydroxy-4-(((tetrahydropyranyl)oxy)methyl)benzene-1,3-dicarboxylate (70percent).

Metal Ion Catalysis by Blocking Inhibitory Reverse Paths in the Hydrolysis of 3-Carboxyaspirin

The hydrolysis of 3-carboxyaspirin (1) was kinetically investigated in the presence or absence of tri- or divalent metal ions.The spontaneous hydrolysis of the neutral and the monoanionic forms of 1 involves anhydride intermediates formed by the nucleophi

A New Aromatic Annelation Reaction with Two Synthons, Enaminones and 3-Oxoglutarate. Studies on the β-Carbonyl Compounds Connected with β-Polyketides. VIII

Reactions of the enaminones 1 with dimethyl 3-oxoglutarate in the presence of KF-AcOH or AcONa-AcOH and 18-crown-6 gave the dimethyl 2-hydroxy-1,3-benzenedicarboxylates 3, providing a new aromatic annelation reaction.Keywords - enaminone; dimethyl 3-oxoglutarate; buffer catalysis; aromatic annelation; dimethyl 2-hydroxy-1,3-benzenedicarboxylate